Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 166, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2022.113228
Keywords
Silver nanoparticles; Silver ions; Rats; Histopathology; Raman spectroscopy; Atomic absorption spectroscopy
Categories
Funding
- U.S. National Science Foundation [1438340, 1726095]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1726095] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1438340] Funding Source: National Science Foundation
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This study investigates the relationship between the biodistribution and toxicity of positively charged silver nanoparticles (AgNPs(+)) and finds that they have adverse effects on the health and systemic functions of rats, especially in spleen.
Although antimicrobial nanosilver finds numerous applications in the health and food industries, the in vivo toxicity of positively charged silver nanoparticles (AgNPs(+)) and relevant controls are largely unexplored. This study investigates the relationship between the biodistribution and toxicity of the well-known cetyl-trimethylammonium bromide (CTAB)-capped AgNPs(+) in 6-weeks old female Sprague-Dawley rats, at sublethal doses. Amounts comparative to those leaked from food products or considered for animal feed were administered through daily water intake, for an 18-day period: AgNPs + (40 mu g mL(-1)), Ag+ (40 ug mL(-1)), antimicrobial CTAB(+) (24 mu g mL(-1)) and tap water. All exposures except for the water control had adverse effects on the health and systemic functions of rats (e.g., lethargy, hepatomegaly, splenomegaly, impediment of bone development, and/or heightened immune response). Although the total Ag accumulation in tissues (1.4-1.6 mu g of Ag/g of liver, spleen, jejunum, and brain) was comparable for the two Ag species, AgNPs(+) were generally more toxic than Ag+, particularly in spleen (0.8 mu g Ag/g). Significantly reduced euthanasia time, alopecia, inflammatory responses in spleen, fragile veins, and enhanced lymphocytosis were observed only for AgNPs(+). Overall, this study raises health concerns about the ingestion of capped-AgNPs(+) or Ag+ by first-hand consumers and industry workers.
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