Journal
FITOTERAPIA
Volume 160, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2022.105216
Keywords
Crataegus pinnatifida; Lignans; Chiral resolution; Enantiomers; Bioinformatics analysis; Neuroprotective activities
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Funding
- LiaoNing Revitalization Talents Program [XLYC2007180]
- Science and Technology Planning Project of Liaoning Province [2021JH1/10400049]
- Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University [ZQN2018006, 2020KTS003]
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In this study, seven lignans were isolated from the fruits of Crataegus pinnatifida, including six new compounds. Their structures were elucidated by spectroscopic analysis and the absolute configurations of two pairs of enantiomers were determined. Furthermore, the neuroprotective effects of these compounds were evaluated, and compound la showed moderate protective effect.
Seven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated for neuroprotective effects toward human neumblastoma SH-SY5Y cells injury induced by H2O2. Among them, compound la exhibited moderate protective effect.
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