Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 127, Issue -, Pages 35-47Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2022.05.055
Keywords
Transcriptomics; Prebiotics; Immune response; Immunostimulants; beta-glucans; Oligosacchari des; Nutrigenomics
Funding
- University of Aberdeen and Skretting Ltd.
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Prebiotics in aquaculture are composed of complex carbohydrate molecules that are metabolized by microbial communities in the host gut. The sources and processing of prebiotics vary between species and types, making it difficult to determine how they work and the host responses. Advances in high-throughput technologies are helping to understand the mechanisms and methods of action of prebiotics.
Within aquaculture, prebiotics are composed of complex carbohydrate molecules that cannot be digested by the fish directly but are metabolised by the microbial communities within the host gut, with the desire that healthy bacterial species are promoted with subsequently improved performance of the fish, there are likely some direct responses of intestinal cells to these dietary components. The sources and processing of prebiotics, which fall under the overarching theme of functional feeds are highly varied between species and types of prebiotics administered. How these feeds exert their effect, and the host responses are hard to determine, but new technologies and the development of high-throughput technologies (omics) are enabling the mechanisms and methods of action to be further understood. The recent advances in the availability of 'omits' technologies with the transition from single gene assays to micmarray and RNA-seq in fish health have enabled novel functional ingredients to be analysed. This review will focus on recent studies on targeted gene expression and 'omics' technologies to characterize immune responses. Comparisons between the immunomodulatory effect of different prebiotics have been made and specific examples of how transcriptomics techniques have been used to identify immune responses to prebiotics are given.
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