Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 127, Issue -, Pages 925-932Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2022.07.038
Keywords
PLEKHF2 proteins; Pattern recognition receptor; Antibacterial activity
Funding
- National Natural Science Foundation of China [31801970]
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This study demonstrates that PLEKHF2 is an antibacterial protein capable of recognizing and killing bacteria.
PLEKHF2 proteins are widespread in animals, but their functions and mechanisms remain poorly defined. Here we clearly demonstrate that PLEKHF2 is a newly identified present abundantly in the eggs/embryos of zebrafish. We also show that recombinant PLEKHF2 acts as a pattern recognition receptor capable of identifying the bacterial signature molecule PGN, LPS, and LTA, binding the bacteria, and functions as an antibacterial effector directly killing the bacteria. In brief, these results indicate that PLEKHF2 is an antibacterial protein, a novel role assigned to PLEKHF2 proteins.
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