Abnormal levels of mitochondrial Ca2+ channel proteins in plasma neuron-derived extracellular vesicles of early schizophrenia

Editorial Material Multidisciplinary Sciences

Genetic origins of schizophrenia find common ground

Conrad O. Iyegbe et al.

Summary: Rare and common genetic variants associated with schizophrenia provide convergent clues about the underlying biology of this complex disorder.

NATURE (2022)

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Article Biology

Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation

Alexandra Stavsky et al.

Summary: NCLX plays a crucial role in regulating presynaptic calcium transients that define synaptic strength, short- and long-term plasticity, which are essential elements of learning and memory processes.

COMMUNICATIONS BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neural cell-derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis

Edward J. Goetzl et al.

Summary: Differences in mitochondrial protein levels were observed between first-episode psychosis patients and controls, suggesting potential correlations with clinical characteristics. Therapeutic interventions targeting the altered protein levels may be beneficial in early phases of schizophrenia.

FASEB JOURNAL (2021)

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Article Multidisciplinary Sciences

Dual-process brain mitochondria isolation preserves function and clarifies protein composition

Maria F. Noterman et al.

Summary: Researching the composition and function of brain mitochondria is challenging but crucial for developing improved neuroprotective therapies.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Physiology

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

Gayathri K. Natarajan et al.

Summary: Despite being discovered nearly two decades ago, the exact function and mechanism of LETM1 protein in the inner mitochondrial membrane remain unresolved. However, LETM1 has been associated with regulating fundamental cellular processes such as development, cellular respiration, metabolism, and apoptosis.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder

Edward J. Goetzl et al.

Summary: Neuronal mitochondrial abnormalities were characterized in major depressive disorder by quantifying functional mitochondrial proteins extracted from enriched plasma neuron-derived extracellular vesicles. Baseline levels of various mitochondrial proteins were found to be significantly different in MDD participants compared to controls, with some showing normalization in participants who responded to SSRI therapy. These findings suggest potential biomarkers for MDD and new drug targets.

MOLECULAR PSYCHIATRY (2021)

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Article Multidisciplinary Sciences