Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 18, Issue 10, Pages 1005-1013Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2022.2108407
Keywords
Environment; gene; inflammatory bowel disease; risk factor; very early onset inflammatory bowel disease
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Inflammatory bowel diseases (IBDs) are influenced by both genetic and environmental factors, with the environment affecting susceptibility and genetic background modulating disease course and phenotype. Understanding gene-environment interactions will contribute to personalized patient management.
Introduction Inflammatory bowel diseases (IBDs) are known to be caused by a combination of genetic and environmental factors that vary in their influence on the development of the disease. Environmental exposures seem to influence IBD susceptibility, whereas genetic background is thought to modulate the impact of the environment on disease course and phenotype. Areas covered A broad review of the involvement of genes and the environment in IBD pathogenesis was performed, and information regarding the main genetic and environmental factors - categorized into lifestyle factors, drugs, diet, and microbes - was updated. Monogenic very early onset IBD (VEO-IBD) was also discussed. Expert opinion In the upcoming years, better understanding of gene-environment interactions will contribute to the possibility of a better prediction of disease course, response to therapy, and therapy-related adverse events with the final goal of personalized and more efficient patient management.
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