4.5 Article

Triple-negative breast cancer drug resistance, durable efficacy, and cure: how advanced biological insights and emerging drug modalities could transform progress

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Emerging drug targets for triple-negative breast cancer: a guided tour of the preclinical landscape

Xuemei Xie et al.

Summary: This narrative review discusses emerging targets for TNBC treatment, challenges in their identification and validation, and future research directions. Overcoming these challenges requires the application of novel technologies and combination therapy for effective disease control.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

Article Biochemistry & Molecular Biology

Smart Lipid-Polysaccharide Nanoparticles for Targeted Delivery of Doxorubicin to Breast Cancer Cells

Manuela Curcio et al.

Summary: In this study, actively-targeted and dual stimuli-responsive lipid-polymer nanoparticles were used to deliver doxorubicin hydrochloride in triple negative breast cancer cell lines. The nanoparticles were efficiently internalized in cancer cells and modulated drug release based on the surrounding pH and redox potential. In vitro experiments demonstrated the safety and efficacy of the nanoparticles in enhancing the cytotoxic effect of the anticancer drug.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Pharmacology & Pharmacy

Heterogeneity of triple-negative breast cancer: understanding the Daedalian labyrinth and how it could reveal new drug targets

Alberto Zambelli et al.

Summary: The authors review the principal biological characteristics of TNBC, including molecular driver alterations, targetable genes, and immune biomarkers. They also summarize the landscape of biomarker-driven therapeutic options in TNBC that emerge from the unique biological basis of the disease.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

Article Biochemistry & Molecular Biology

Enhanced DNA damage response through RAD50 in triple negative breast cancer resistant and cancer stem-like cells contributes to chemoresistance

Etna Abad et al.

Summary: The growing body of evidence suggests that cancer resistance is driven by a small subset of cancer stem cells, which share common qualities to activate self-defense mechanisms. Rad50, with enhanced DNA damage response, has been identified as a key contributor to tumor cell resistance.

FEBS JOURNAL (2021)

Article Nanoscience & Nanotechnology

Synergistic co-loading of vincristine improved chemotherapeutic potential of pegylated liposomal doxorubicin against triple negative breast cancer and non-small cell lung cancer

Saikat Ghosh et al.

Summary: This study explored the biological characteristics of co-loading vincristine with pegylated liposomal doxorubicin in non-small cell lung cancer and triple negative breast cancer. Results showed significantly increased cellular uptake, cell cycle arrest, apoptosis, and reduced cell viability with the co-loaded liposome formulation compared to doxorubicin liposome, leading to improved therapeutic efficacy in vitro and in vivo against NSCLC and TNBC.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

Article Oncology

Phase II Trial of Neoadjuvant Carboplatin and Nab-Paclitaxel in Patients with Triple-Negative Breast Cancer

Yuan Yuan et al.

Summary: The combination of carboplatin and nab-paclitaxel showed manageable toxicity and encouraging antitumor activity in early stage high-risk triple-negative breast cancer. Immune-hot GSIS was associated with higher pCR rate and RCB class 0/1, providing rationale for future neoadjuvant trials in TNBC. Additional development of GSIS as a clinically applicable assay is indicated.

ONCOLOGIST (2021)

Article Oncology

Inhibition of interferon-signalling halts cancer-associated fibroblast-dependent protection of breast cancer cells from chemotherapy

Robyn Broad et al.

Summary: CAFs induce activation of IFN signaling in claudin-low TNBCs, leading to chemoresistance. High expression of IFN beta 1 (CAFs) or MX1 (tumour cells) correlates with reduced survival after chemotherapy, especially in claudin-low subtype tumors.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?

Xupeng Bai et al.

Summary: TNBC shows higher response rate to systemic therapy but poorer tumor differentiation, with higher tendency to metastasis and recurrence. Relapsed and metastatic TNBCs progress more rapidly, demonstrating strong resistance to chemotherapy and radiotherapy.

CANCER LETTERS (2021)

Review Pharmacology & Pharmacy

Novel immune targets for the treatment of triple-negative breast cancer

Chiara Corti et al.

Summary: The article discusses the landscape of immune therapeutics investigated in early-phase clinical trials for TNBC, providing preclinical rationale, predominant expression, and function for each immune target, as well as discussing the clinical implications and preliminary trial results. Most immune strategies showed signs of anti-cancer activity and good safety profile in early-phase clinical trials, highlighting the importance of predictive biomarkers for refining patient selection in TNBC treatment.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

Article Cell & Tissue Engineering

Signaling pathways essential for triple-negative breast cancer stem-like cells

Sidse Ehnnsen et al.

Summary: Breast cancer stem cells play a crucial role in cancer initiation, therapy resistance, and progression, with recent research focusing on cellular signaling pathways such as the WNT pathway, NF-κB pathway, and cholesterol biosynthesis pathway. Targeting these pathways in combination with standard treatments may improve the prognosis of breast cancer patients.

STEM CELLS (2021)

Article Oncology

Friend or foe: ABCG2, ABCC1 and ABCB1 expression in triple-negative breast cancer

Milica Nedeljkovic et al.

Summary: ABC transporters play a key role in chemoresistance of solid tumors, with higher expression in TNBC compared to ER+ breast cancer. Among the three transporters studied, ABCG2 and ABCC1 showed significantly higher levels of expression in TNBC compared to ABCB1, with ABCB1 associated with metastatic spread in TNBC patients. Surprisingly, high expression of ABCG2 was correlated with longer disease-free interval and overall survival in TNBC patients.

BREAST CANCER (2021)

Article Chemistry, Multidisciplinary

Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

Fadak Howaili et al.

Summary: In this study, a dual-responsive nanogel system with the incorporation of gold nanoparticles for drug delivery and photothermal therapy was synthesized. Characterization of the nanogel and evaluation of its cytocompatibility were conducted, showing promising potential for cancer therapy.

FRONTIERS IN CHEMISTRY (2021)

Article Cell Biology

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

Dawid Mehlich et al.

Summary: The study demonstrates that MLK4 promotes TNBC chemoresistance by regulating the pro-survival response to DNA-damaging therapies, while its silencing enhances sensitivity to chemotherapy and induces DNA damage accumulation and apoptosis in TNBC cells. MLK4 is also essential for DNA damage response signaling and expression of NF-kB-associated cytokines. Furthermore, high MLK4 expression is associated with worse overall survival in TNBC patients receiving anthracycline-based neoadjuvant chemotherapy.

CELL DEATH & DISEASE (2021)

Article Oncology

The Oxygen-Generating Calcium Peroxide-Modified Magnetic Nanoparticles Attenuate Hypoxia-Induced Chemoresistance in Triple-Negative Breast Cancer

Fong-Yu Cheng et al.

Summary: Tumor hypoxia increases chemotherapy resistance in TNBC, but CaO2-MNPs can improve this by promoting apoptosis in TNBC cells and enhancing the efficacy of doxorubicin treatment.

CANCERS (2021)

Article Oncology

Overexpression of EZH2/NSD2 Histone Methyltransferase Axis Predicts Poor Prognosis and Accelerates Tumor Progression in Triple-Negative Breast Cancer

Bo Gao et al.

Summary: In breast cancer, the overexpression of EZH2 and NSD2 is associated with tumor grade and lymph node metastasis, and negatively correlates with RFS and DMFS. In TNBC, the EZH2/NSD2 axis may serve as a predictive marker for poor prognosis and disease progression.

FRONTIERS IN ONCOLOGY (2021)

Article Cell Biology

Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells

Veronica Vella et al.

Summary: IR-A is more potent than IR-B in mediating insulin signaling in TNBC cells, inducing genes related to tumor progression and immune evasion, while IR-B primarily regulates metabolic pathways and angiogenesis; approximately 89% of insulin-stimulated transcripts depend solely on the expression of the specific isoform.

CELLS (2021)

Article Oncology

Atractylenolide-I Sensitizes Triple-Negative Breast Cancer Cells to Paclitaxel by Blocking CTGF Expression and Fibroblast Activation

Meng Wang et al.

Summary: ATL-1 sensitizes TNBC cells to paclitaxel by inhibiting CTGF expression and fibroblast activation, reducing tumor cell migration and enhancing therapeutic efficacy.

FRONTIERS IN ONCOLOGY (2021)

Article Chemistry, Multidisciplinary

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

Aroa Duro-Castano et al.

Summary: The research team utilized poly-amino acid-based nanogels (NGs) as a drug delivery platform to successfully inhibit TNBC lung metastasis and almost completely suppress lymph node metastasis in a mouse model.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Oncology

BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation

Siqi Li et al.

Summary: BOP1 plays a crucial role in chemoresistance of TNBC, and its overexpression is associated with poor prognosis in patients, indicating it may serve as a therapeutic target.

JOURNAL OF PATHOLOGY (2021)

Article Chemistry, Multidisciplinary

ICG-Loaded PEG-Modified Black Phosphorus Nanosheets for Fluorescence Imaging-Guided Breast Cancer Therapy

Wanwan Pan et al.

Summary: ICG-loaded poly(ethylene glycol) (PEG)-modified BPNS (ICG@BPNS-PEG) nanocomposites have been successfully constructed with improved tumor-targeting capacity and guidance for photothermal therapy, exhibiting good photostability and enhanced photothermal conversion ability. The nanocomposites show lower cytotoxicity and good cellular compatibility, as well as satisfactory photothermal therapeutic effects, indicating substantial potential in breast cancer therapy.

ACS OMEGA (2021)

Article Medicine, General & Internal

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

A. Bardia et al.

Summary: Patients with metastatic triple-negative breast cancer treated with Sacituzumab govitecan had significantly longer progression-free and overall survival compared to standard chemotherapy, but experienced more frequent myelosuppression and diarrhea as adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

A smart viral vector for targeted delivery of hydrophobic drugs

Sukanya Ghosh et al.

Summary: By utilizing Flock House Virus-like particles as carriers and an easy chemical conjugation method, targeted delivery of hydrophobic drugs can be achieved effectively with dual functionality for improved bioavailability and reduced immune reactivity. The platform shows promising potential for biomedical applications.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies

Vivek Kumar et al.

Summary: Resistance to therapy is a major challenge in cancer management, with cancer cells rewiring their cellular processes to resist the deleterious effects of various therapeutic approaches. Understanding the role of developmental pathways in cancer and their contribution to resistance can lead to insights for developing novel therapeutic approaches. Recognizing the importance of molecular networks in overcoming drug resistance can provide a rational basis for improving cancer treatment with safer and more effective combined therapeutic strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

Yanghong Ni et al.

Summary: The tumor microenvironment plays a crucial role in regulating immune escape, drug resistance, progression, and metastasis of malignant cells, as interactions between cancer cells and non-malignant cells often promote drug resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway

Huayu Hu et al.

Summary: Research has shown that PIK3CA mutation promotes the growth and migratory ability of tumor cells in TNBC, while also inhibiting the apoptosis process. This mutation leads to chemotherapy resistance in TNBC.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Oncology

A randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida)

Lori J. Goldstein et al.

Summary: The addition of reparixin to first-line therapy with paclitaxel did not significantly prolong progression-free survival in metastatic triple-negative breast cancer patients.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Review Oncology

Checkpoint inhibitor therapy for metastatic triple-negative breast cancer

Arielle L. Heeke et al.

Summary: Immunotherapy has become a key component in the treatment of cancer, with promising activity observed in metastatic triple-negative breast cancer (TNBC) through PD-1/PD-L1 checkpoint inhibitor therapy. Accelerated approvals by the FDA for atezolizumab and pembrolizumab in 2019 and 2020, respectively, have provided hope for the treatment of PD-L1-positive TNBC.

CANCER AND METASTASIS REVIEWS (2021)

Article Oncology

Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer

Kurt W. Evans et al.

Summary: Oxidative phosphorylation is a metabolic vulnerability in triple-negative breast cancer, and inhibiting it with IACS-10759 may enhance efficacy of multiple targeted therapies.

CANCER RESEARCH (2021)

Article Nanoscience & Nanotechnology

Improved Anti-Triple Negative Breast Cancer Effects of Docetaxel by RGD-Modified Lipid-Core Micelles

Rujing Chen et al.

Summary: The novel RGD-modified PEGylated lipid-core micelle delivery system significantly improved the anti-cancer effects of docetaxel on TNBC, reducing side-effects and providing a promising therapeutic approach for TNBC treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Biochemistry & Molecular Biology

Dual Functions of Riboflavin-functionalized Poly(lactic-co-glycolic acid) Nanoparticles for Enhanced Drug Delivery Efficiency and Photodynamic Therapy in Triple-negative Breast Cancer Cells

Wid Mekseriwattana et al.

Summary: This study demonstrated the use of modified PLGA-CSRf nanoparticles as both drug delivery ligands and photodynamic therapy agents for TNBC cells. The biocompatibility of the nanoparticles was confirmed in both breast cancer and normal breast cells, with a significant increase in cellular uptake in cancer cells compared to normal cells. The results suggest that riboflavin can enhance the delivery of PLGA nanoparticles to TNBC cells and improve the therapeutic effects of combined drug delivery and photodynamic therapy.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Biomimetic black phosphorus quantum dots-based photothermal therapy combined with anti-PD-L1 treatment inhibits recurrence and metastasis in triple-negative breast cancer

Peiqi Zhao et al.

Summary: This study developed a combined photothermal immunotherapy strategy using BBPQDs for TNBC treatment, showing enhanced antitumor activity compared to anti-PD-L1 monotherapy. The strategy effectively inhibits tumor recurrence and metastasis by reprogramming the tumor microenvironment and inducing immune memory against tumor rechallenge.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Oncology

Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer

Pere Llinas-Arias et al.

Summary: The outcomes of triple-negative breast cancer (TNBC) are improving with the introduction of immunotherapy, but these responses are still limited to a select group of patients. Epigenetic alterations play a crucial role in immune escape mechanisms in TNBC, and the combination of epigenetic drugs and immunotherapy may enhance anticancer immune responses. Further research on the crosstalk between epigenetics and immune responses in TNBC is essential for developing effective therapeutic strategies.

CANCERS (2021)

Review Oncology

Cancer-Associated Fibroblasts in Breast Cancer Treatment Response and Metastasis

Patricia Fernandez-Nogueira et al.

Summary: Breast cancer is a major public health issue with significant impact on patients and their families. Early detection is crucial for successful treatment, as therapy resistance and metastases are critical clinical challenges. Cancer-associated fibroblasts play a key role in therapy resistance and metastasis, highlighting the importance of targeting CAFs for overcoming resistance and preventing metastases. Advances in biomarkers and genetic analysis have allowed for personalized treatment strategies in breast cancer management.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Dihydrotestosterone Induces Chemo-Resistance of Triple-Negative Breast MDA-MB-231 Cancer Cells Towards Doxorubicin Independent of ABCG2 and miR-328-3p

Bayan Al-Momany et al.

Summary: Through experiments, it was found that DHT can regulate cell resistance to doxorubicin in TNBC cells, not by affecting the levels of miR-328-3p and ABCG2, but through another mechanism.

CURRENT MOLECULAR PHARMACOLOGY (2021)

Article Cell Biology

Identification of TAZ-Dependent Breast Cancer Vulnerabilities Using a Chemical Genomics Screening Approach

He Shen et al.

Summary: The study shows the rapid generation of experimentally induced breast cancer stem cells by TAZ-mediated reprogramming, allowing for direct analysis of BCSC phenotypes. Genetically defined TAZ-dependent and -independent cell lines with distinct cancer stem cell traits reveal a critical TAZ-CCND1-CDK4/CDK6 signaling axis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer

Jia-hui Ye et al.

Summary: The study revealed that the infiltration level of CD163(+) macrophages was closely associated with chemotherapeutic response and survival rate in TNBC patients, indicating that TAMs may serve as predictive indicators for NAC treatment and potential prognostic markers for poor survival in TNBC patients.

JOURNAL OF CANCER (2021)

Article Nanoscience & Nanotechnology

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

Alfredo Nunez-Rivera et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2020)

Review Pharmacology & Pharmacy

Cancer associated fibroblasts: role in breast cancer and potential as therapeutic targets

Rosamaria Lappano et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

Article Biochemistry & Molecular Biology

Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer

Crystal C. Lipsey et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

Ozge Saatci et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Metabolic Reprogramming in Triple-Negative Breast Cancer

Sun Xiangyu et al.

FRONTIERS IN ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells

Andrew Sulaiman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Pharmacology & Pharmacy

Macrophages confer resistance to BET inhibition in triple-negative breast cancer by upregulating IKBKE

Jianghua Qiao et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Nanoscience & Nanotechnology

Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer

Christopher M. Bailey et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Article Chemistry, Multidisciplinary

Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids

John D. Schneible et al.

PHARMACEUTICAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines

Floren G. Low et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer

Vikas Jain et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Multidisciplinary Sciences

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

Qin Wu et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, Research & Experimental

Molecular mechanisms of breast cancer chemoresistance by immune checkpoints

Narges Dastmalchi et al.

LIFE SCIENCES (2020)

Article Medicine, Research & Experimental

Cisplatin Prodrug-Loaded Nanoparticles Based on Physalis Mottle Virus for Cancer Therapy

He Hu et al.

MOLECULAR PHARMACEUTICS (2020)

Review Cell Biology

Estrogen Actions in Triple-Negative Breast Cancer

Oliver Treeck et al.

CELLS (2020)

Article Oncology

Exploiting DNA repair defects in triple negative breast cancer to improve cell killing

Kevin J. Lee et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2020)

Article Materials Science, Biomaterials

A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

Lairong Ding et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Materials Science, Biomaterials

Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy

Pinar Sinem Omurtag Ozgen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Article Cell Biology

Loss of MCL1 function sensitizes the MDA-MB-231 breast cancer cells to rh-TRAIL by increasing DR4 levels

Anna De Blasio et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Oncology

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

Damiano Cosimo Rigiracciolo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Oncology

The role of photodynamic therapy on multidrug resistant breast cancer

Eric Chekwube Aniogo et al.

CANCER CELL INTERNATIONAL (2019)

Article Oncology

TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer

Utpal K. Mukhopadhyay et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Article Cell Biology

Aurora kinase A stabilizes FOXM1 to enhance paclitaxel resistance in triple-negative breast cancer

Na Yang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Article Endocrinology & Metabolism

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status

Shuang Ye et al.

ENDOCRINE CONNECTIONS (2019)

Review Oncology

The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?

Priyanka Bhateja et al.

CANCERS (2019)

Article Multidisciplinary Sciences

Anti-tumor activity of BET inhibitors in androgen-receptor- expressing triple-negative breast cancer

In Hae Park et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells

Anna A. Marusiak et al.

ONCOGENE (2019)

Article Biochemistry & Molecular Biology

Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2

Arunkumar Arumugam et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Article Biochemistry & Molecular Biology

TGF-beta plays a vital role in triple-negative breast cancer (TNBC) drug-resistance through regulating sternness, EMT and apoptosis

Xiaodan Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism

Marco Fiorillo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2018)

Review Biochemistry & Molecular Biology

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

Matteo Santoni et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

Article Biochemistry & Molecular Biology

Interleukin-6 contributes to chemoresistance in MDA-MB-231 cells via targeting HIF-1α

Ke Wang et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

Article Multidisciplinary Sciences

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Cell Biology

ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

Xiang Zhang et al.

CELL DEATH & DISEASE (2018)

Article Cell & Tissue Engineering

HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway

Yi Liu et al.

STEM CELL REPORTS (2018)

Review Immunology

Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target?

Mahnaz Janghorban et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Medicine, Research & Experimental

Novel folic acid-conjugated doxorubicin loaded β-lactoglobulin nanoparticles induce apoptosis in breast cancer cells

Zahra Kayani et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Environmental Sciences

Cellular uptake and apoptotic potential of rhenium labeled magnetic protein cages in MDA-MB-231 cells

Elif Asik et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Jordan M. Reese et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Medicine, General & Internal

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Gaofeng Xiong et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

Targeting DNA Repair in Cancer : Beyond PARP Inhibitors

Jessica S. Brown et al.

CANCER DISCOVERY (2017)

Article Biotechnology & Applied Microbiology

The impact of the codelivery of drug-siRNA by trimethyl chitosan nanoparticles on the efficacy of chemotherapy for metastatic breast cancer cell line (MDA-MB-231)

Peyman Eivazy et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

Article Materials Science, Biomaterials

Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer

Bing Feng et al.

BIOMATERIALS SCIENCE (2017)

Article Oncology

Breast cancer subtype distribution is different in normal weight, overweight, and obese women

Victoria Gershuni et al.

BREAST CANCER RESEARCH AND TREATMENT (2017)

Article Biochemistry & Molecular Biology

Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis

Shadia Al-Bahlani et al.

APOPTOSIS (2017)

Review Pharmacology & Pharmacy

Triple negative breast cancer chemosensitivity and chemoresistance: current advances in biomarkers indentification

Fouzia Guestini et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

Article Biochemistry & Molecular Biology

Transforming growth factor-beta increases breast cancer stem cell population partially through upregulating PMEPA1 expression

Zhi Nie et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2016)

Article Medicine, Research & Experimental

Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer

Mengmeng Niu et al.

MOLECULAR PHARMACEUTICS (2016)

Article Biochemistry & Molecular Biology

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Fara Braso-Maristany et al.

NATURE MEDICINE (2016)

Review Oncology

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Biochemistry & Molecular Biology

β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer

Hsin-Ling Yin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Oncology

Expression of FGFR1 is an independent prognostic factor in triple-negative breast cancer

Chee Leong Cheng et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Article Multidisciplinary Sciences

A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness

Tackhoon Kim et al.

NATURE COMMUNICATIONS (2015)

Article Biotechnology & Applied Microbiology

RNA-Based TWIST1 Inhibition via Dendrimer Complex to Reduce Breast Cancer Cell Metastasis

James Finlay et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Pharmacology & Pharmacy

Triple-negative breast cancer: investigating potential molecular therapeutic target

Anselmo Papa et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Article Biochemistry & Molecular Biology

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

M. Bartucci et al.

ONCOGENE (2015)

Article Engineering, Biomedical

Hydrogel Doped with Nanoparticles for Local Sustained Release of siRNA in Breast Cancer

Nathaly Segovia et al.

ADVANCED HEALTHCARE MATERIALS (2015)

Article Chemistry, Multidisciplinary

Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

Teng Liu et al.

ADVANCED MATERIALS (2014)

Article Biophysics

Peptide conjugated polymeric nanoparticles as a carrier for targeted delivery of docetaxel

Hitesh Kulhari et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

Review Oncology

Unique Features of Young Age Breast Cancer and Its Management

Han-Byoel Lee et al.

JOURNAL OF BREAST CANCER (2014)

Article Biochemistry & Molecular Biology

GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17β-estradiol in triple-negative breast cancer cells

Tenghua Yu et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Xi Chen et al.

NATURE (2014)

Article Multidisciplinary Sciences

被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell & Tissue Engineering

Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1

Dong Soon Choi et al.

STEM CELLS (2014)

Review Endocrinology & Metabolism

GPER function in breast cancer: an overview

Rosamaria Lappano et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Review Immunology

Immunogenic Cell Death in Cancer Therapy

Guido Kroemer et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Oncology

Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer

Maxwell N. Skor et al.

CLINICAL CANCER RESEARCH (2013)

Article Biochemistry & Molecular Biology

IMP3 Protein Promotes Chemoresistance in Breast Cancer Cells by Regulating Breast Cancer Resistance Protein (ABCG2) Expression

Sanjoy Samanta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Medicine, Research & Experimental

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

Neil E. Bhola et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes

Enilze Ribeiro et al.

PLOS ONE (2013)

Article Biotechnology & Applied Microbiology

Cytotoxicity of Biologically Synthesized Silver Nanoparticles in MDA-MB-231 Human Breast Cancer Cells

Sangiliyandi Gurunathan et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Review Biotechnology & Applied Microbiology

A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

Fatemeh Karami et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Engineering, Biomedical

Cisplatin@US-tube carbon nanocapsules for enhanced chemotherapeutic delivery

Adem Guven et al.

BIOMATERIALS (2012)

Article Chemistry, Multidisciplinary

PEGylated Liposomal Doxorubicin Targeted to α5β1-Expressing MDA-MB-231 Breast Cancer Cells

Kamlesh Shroff et al.

LANGMUIR (2012)

Review Biochemistry & Molecular Biology

Functional Aspects of PARP1 in DNA Repair and Transcription

Hui Ling Ko et al.

BIOMOLECULES (2012)

Article Cell Biology

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Tanaya Shree et al.

GENES & DEVELOPMENT (2011)

Article Medicine, Research & Experimental

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Brian D. Lehmann et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Oncology

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression

Scott M. Welford et al.

MOLECULAR CANCER RESEARCH (2011)

Editorial Material Multidisciplinary Sciences

CANCER Macrophages limit chemotherapy

Michele De Palma et al.

NATURE (2011)

Article Medicine, Research & Experimental

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Christophe Ginestier et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Biochemistry & Molecular Biology

Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia

Lionel Flamant et al.

MOLECULAR CANCER (2010)

Article Biochemistry & Molecular Biology

Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway

Rafael Cubas et al.

MOLECULAR CANCER (2010)

Review Oncology

ABC transporters in cancer: more than just drug efflux pumps

Jamie I. Fletcher et al.

NATURE REVIEWS CANCER (2010)

Article Chemistry, Multidisciplinary

Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

David Brevet et al.

CHEMICAL COMMUNICATIONS (2009)

Article Multidisciplinary Sciences

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

Chad J. Creighton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Oncology

Triple-negative breast cancer: Clinical features and patterns of recurrence

Rebecca Dent et al.

CLINICAL CANCER RESEARCH (2007)

Review Oncology

Hypoxia-driven selection of the metastatic phenotype

Richard Sullivan et al.

CANCER AND METASTASIS REVIEWS (2007)

Article Oncology

The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes

Lisa A. Carey et al.

CLINICAL CANCER RESEARCH (2007)

Article Oncology

MRP8/ABCC11 directly confers resistance to 5-fluorouracil

Tetsuya Oguri et al.

MOLECULAR CANCER THERAPEUTICS (2007)

Review Oncology

The role of the BRCA1 tumor suppressor in DNA double-strand break repair

JR Zhang et al.

MOLECULAR CANCER RESEARCH (2005)

Article Genetics & Heredity

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair

AR Hartman et al.

NATURE GENETICS (2002)