☆ 4.6 Review

Cancer bone metastases and nanotechnology-based treatment strategies

EXPERT OPINION ON DRUG DELIVERY (2022)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Nanokit coupled electrospray ionization mass spectrometry for analysis of angiotensin converting enzyme 2 activity in single living cell

Xinqi Chang et al.

Summary: The activity of ACE2 in single living cells was determined for the first time using a nanokit coupled electrospray ionization mass spectrometry. The measurement showed that the inflammatory state of cells does not significantly affect ACE2 catalytic activity, elucidating the relationship between intracellular ACE2 activity and inflammation.

CHINESE CHEMICAL LETTERS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Intervention with the Bone-Associated Tumor Vicious Cycle through Dual-Protein Therapeutics for Treatment of Skeletal-Related Events and Bone Metastases

Yimin Niu et al.

Summary: Bone metastasis is a common phenomenon in lung cancer, prostate cancer, and other malignant tumors. In this study, biomineralized metal-organic framework (MOF) nanoparticles carrying protein toxins and combined with RANKL antibody were constructed to effectively treat bone metastases and reduce skeletal-related events (SREs).

ACS NANO (2022)

Add to Collection

Article Pharmacology & Pharmacy

The impact of protein corona on the biological behavior of targeting nanomedicines

Masoud Farshbaf et al.

Summary: In order to successfully translate targeting nanomedicines from bench to bedside, it is necessary to address the common issues of rapid clearance and off-target accumulation. This phenomenon, known as protein corona (PC) formation, occurs when targeting nanoparticles encounter the bloodstream and interact with plasma proteins. The present review discusses the impact of PC on the biological behavior of targeting nanomedicines, as well as the best simulated environment and latest characterization techniques for PC analysis. The article also highlights recent progress in manipulating nano-bio interfaces to achieve optimal therapeutic outcomes.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Targeting bone microenvironments for treatment and early detection of cancer bone metastatic niches

Hongbin Yang et al.

Summary: The article discusses the harmful effects of bone metastasis on many cancers and the impact of dynamic interactions between tumor cells and bone tissues on tumor growth and progression. It proposes clinical benefits of targeting bone microenvironments to improve cure rates and reduce related diseases. It also examines research on using nano drugs and probes to inhibit tumor migration and detect early bone metastasis.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

PMMA Bone Cement Composite Functions as an Adjuvant Chemotherapeutic Platform for Localized and Multi-Window Release during Bone Reconstruction

Erika L. Cyphert et al.

Summary: A refillable chemotherapeutic (doxorubicin, DOX) delivery platform using PMMA bone cement and gamma-cyclodextrin (gamma-CD) polymeric microparticles has been developed for bone reconstruction. The platform can release chemotherapeutics and has the potential for customized dosing regimens.

MACROMOLECULAR BIOSCIENCE (2022)

Add to Collection

Article Multidisciplinary Sciences

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Min Qiu et al.

Summary: The challenge of delivering mRNA to specific organs and cells in vivo is being addressed, with research showing that N-series LNPs can selectively deliver mRNA to the lungs while O-series LNPs tend to deliver mRNA to the liver. By analyzing the protein corona on targeted LNPs, unique plasma proteins were identified that contribute to their targetability. This research demonstrates the potential of LNPs as a promising therapeutic intervention for lung diseases like lymphangioleiomyomatosis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Shaojun Peng et al.

Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.

ADVANCED SCIENCE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Intelligent lesion blood-brain barrier targeting nano-missiles for Alzheimer?s disease treatment by anti-neuroinflammation and neuroprotection

Xueqin He et al.

Summary: This study established a drug co-delivery system for Alzheimer's disease that efficiently targets the neurovascular unit in AD lesions and specifically releases drugs in astrocytes in response to high levels of ROS. It significantly improves cognition, reduces beta-amyloid plaques, alleviates neurotoxicity, and inhibits neuroinflammation in AD mice.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection

Review Engineering, Biomedical

The horizon of bone organoid: A perspective on construction and application

Shuangshuang Chen et al.

Summary: The repair and regeneration of bone defects caused by various factors have always been a key issue in clinical practice. Bone tissue engineering technology has greatly accelerated the speed and quality of bone regeneration by providing functional scaffold materials and seed cells. However, the complicated bone metabolism mechanism poses challenges to research in bone regeneration. Organoids, as a new concept, show promising application prospects in organ development, drug screening, and mechanism study.

BIOACTIVE MATERIALS (2022)

Add to Collection

Article Oncology

Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer

Juening Kang et al.

Summary: During the progression of prostate cancer, particularly in bone metastases, the tumor microenvironment (TME) undergoes changes that support tumor spread and colonization at distant sites. This article discusses the profile of advanced metastatic prostate cancer and genetic alterations. It also explores the role of the TME, particularly the extracellular matrix and fibroblast cells, in different stages of metastatic spread and bone metastasis. Evidence of premetastatic niche formation, stromal similarities between primary prostate cancer and bone metastasis, and the contribution of the TME to androgen deprivation therapy resistance are presented. The article also provides an overview of transgenic mouse models for studying bone metastasis and current diagnostic and therapeutic strategies.

CANCER LETTERS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids

Sanghee Lee et al.

Summary: Patients with advanced prostate cancer and bone metastases often develop resistance to androgen pathway directed therapy (APDT). By establishing patient-derived xenograft (PDX)-derived organoids, researchers identified neurogenic and steroidogenic gene upregulation and downregulation of DNA repair, cell cycle, and other pathways as resistance mechanisms. They also discovered that enzalutamide induced a reversible dormant state in the organoids.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Oncology

Evolving cancer-niche interactions and therapeutic targets during bone metastasis

Robert L. Satcher et al.

Summary: The metastasis of cancer to bone is influenced by genetic traits of the primary tumor and interactions with the bone microenvironment. Understanding these interactions is crucial in determining the fate of cancer cells during metastasis. Further research is needed to explore common and distinct features of bone metastasis in different cancer types to develop more effective therapies.

NATURE REVIEWS CANCER (2022)

Add to Collection

Review Engineering, Biomedical

PEGYLATION: an important approach for novel drug delivery system

Deepa Yadav et al.

Summary: PEGylation is a technique for improving the maintenance time and beneficial properties of drugs by covalently attaching polyethylene glycol (PEG) to molecules. It plays an important role in enhancing the therapeutic potential and drug delivery system，and is widely used in pharmaceutical field to improve drug properties.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2021)

Add to Collection

Review Engineering, Biomedical

Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges

Xin Gao et al.

Summary: This review focuses on the principles and methods in the design of targeted nanoparticles for the diagnosis and therapy of orthotopic and metastatic bone tumors. Various ligands have been grafted on nanoparticles for bone targeting, and different targeting strategies using monoclonal antibodies, peptides, and aptamers have been explored for diagnosis and therapy. The development of multifunctional nanoparticles to disrupt the vicious cycle between tumor cell proliferation and bone resorption, as well as the challenges and perspectives in this area, are also discussed.

BIOMATERIALS (2021)

Add to Collection

Article Pharmacology & Pharmacy

The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials

Xi Cheng et al.

Summary: The importance of optimized drug delivery systems for the treatment of cancer metastatic osteolysis was discussed in this review, introducing some novel nanotechnology and nanomaterials that offer new perspectives for scientists.

DRUG DELIVERY (2021)

Add to Collection

Article Chemistry, Medicinal

PSMA-targeted low-molecular double conjugates for diagnostics and therapy

Stanislav A. Petrov et al.

Summary: This review discusses the use of dual conjugates for targeted delivery to prostate cancer cells, focusing on low-molecular-weight conjugates directed to PSMA, and comparing high and low molecular weight PSMA-targeted conjugates. It also categorizes the conjugates into diagnostic bimodal and theranostic conjugates, as well as briefly mentioning bimodal high molecular weight therapeutic conjugates with two therapeutic agents. In vitro and in vivo studies for PSMA-targeted double conjugates available by the beginning of 2021 were analyzed.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection

Review Physiology

BONEMETASTASIS: MECHANISMS, THERAPIES, AND BIOMARKERS

Philippe Clezardin et al.

Summary: Skeletal metastases are common complications of many cancers, significantly impacting patients' quality of life. The multistage process of bone metastasis involves various cellular and molecular mechanisms. While existing bone-targeted agents have made progress, further research and more effective treatment options are still needed.

PHYSIOLOGICAL REVIEWS (2021)

Add to Collection

Review Oncology

Bone cement as a local chemotherapeutic drug delivery carrier in orthopedic oncology: A review

Sunjeev S. Phull et al.

Summary: Metastatic bone lesions are commonly treated by reconstructive surgery, with potential use of cement as carriers for chemotherapeutic drugs. Studies have shown benefits in providing high local drug concentrations, but local toxic effects on healthy bone structure have been reported, indicating the need for careful materials selection in future treatments for metastatic bone disease.

JOURNAL OF BONE ONCOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Shape Transformable Strategies for Drug Delivery

Wenfeng Jia et al.

Summary: Nanoparticle shape significantly influences drug delivery efficacy, with transformable shapes achieved through internal or external stimuli enhancing delivery efficiency in time and space. This promising prospect may lead to improved cancer treatment in the future.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Review Chemistry, Analytical

Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma

Mahmood Barani et al.

Summary: Osteosarcoma is a rare bone cancer derived from mesenchymal stem cells, primarily caused by factors like genome disorganization and chromosomal modifications. Despite advances in diagnosis and treatment, overall survival for patients has not improved significantly in the past two decades. Modern nanotechnology has offered advantages in managing osteosarcoma and functionalized nanomaterials have found widespread applications in combating its progression.

BIOSENSORS-BASEL (2021)

Add to Collection

Review Oncology

Emerging roles for myeloid immune cells in bone metastasis

Massar Alsamraae et al.

Summary: Metastasis, especially bone metastasis, is a major cause of cancer-related deaths, linked to long-term pain and poor quality of life. Tumor cells alter the bone microenvironment, leading to cancer growth, but bone-targeted therapies have shown limited improvement in patient survival.

CANCER AND METASTASIS REVIEWS (2021)

Add to Collection

Review Oncology

The multifaceted roles of the chemokines CCL2 and CXCL12 in osteophilic metastatic cancers

Elora Midavaine et al.

Summary: The chemokines CCL2 and CXCL12, along with their receptors CCR2 and CXCR4, play a central role in the formation and development of bone metastases, influencing tumor cell survival, growth, and migration. Understanding the pathophysiology of bone metastases is crucial for reducing the skeletal tumor burden in patients.

CANCER AND METASTASIS REVIEWS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The bone microenvironment invigorates metastatic seeds for further dissemination

Weijie Zhang et al.

Summary: Metastasis is often considered the final step of tumor progression, but recent studies show that many metastases are initiated by the further spread of existing metastases. Through experiments, it was found that the bone microenvironment can facilitate cancer cells to further metastasize and establish secondary metastases in multiple organs. This metastasis-promoting effect is driven by epigenetic reprogramming that confers stem cell-like properties on disseminated cancer cells.

CELL (2021)

Add to Collection

Review Chemistry, Multidisciplinary

The progress and perspective of strategies to improve tumor penetration of nanomedicines

Jiang Hu et al.

Summary: This article discusses the importance of tumor penetration, analyzes the barriers to tumor penetration, and discusses strategies such as modulating the tumor microenvironment to enhance tumor penetration.

CHINESE CHEMICAL LETTERS (2021)

Add to Collection

Article Cell Biology

The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

Igor L. Bado et al.

Summary: Estrogen receptor-positive (ER+) breast cancer shows strong bone tropism in metastasis, with the bone microenvironment impacting ER signaling and endocrine therapy. The osteogenic niche transiently reduces ER expression and activities specifically in bone micrometastases, leading to endocrine resistance. EZH2-mediated epigenomic reprogramming drives ER+ BMMs towards a basal and stem-like state, and EZH2 inhibition reverses endocrine resistance.

DEVELOPMENTAL CELL (2021)

Add to Collection

Review Cell Biology

Mechanisms, Diagnosis and Treatment of Bone Metastases

Jozef Ban et al.

Summary: Bone and bone marrow are common metastatic sites of cancer, often associated with poor disease prognosis. Current therapeutic options for bone metastases are limited and mainly palliative. Further research into the molecular pathways of bone metastasis is needed to develop more successful treatments for improved patient outcomes.

CELLS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Unmasking CSF protein corona: Effect on targeting capacity of nanoparticles

Yazhen Wang et al.

Summary: The formation of protein corona from cerebrospinal fluid can impact the targeting capability of nanoparticles, leading to the loss of active targeting specificity and alteration of their cellular uptake pathways.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Advances of nanomedicines in breast cancer metastasis treatment targeting different metastatic stages

Wenqi Yu et al.

Summary: Breast cancer is the most common tumor in women and its metastasis increases malignancy and mortality. Nanomedicines have shown great potential in treating cancer metastasis by specifically designed functions at different stages of the process, providing new solutions.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Delivered Supramolecular Nanomedicine with Transformable Shape for Ferrocene-Amplified Photodynamic Therapy of Breast Cancer and Bone Metastases

Yi Qin et al.

Summary: The study developed a self-delivery supramolecular nanoplatform with shape-transforming capacity and enhanced retention effect, which can release ROS in the tumor microenvironment and trigger cascade reactions to alleviate hypoxia and enhance photodynamic therapy efficacy.

ADVANCED FUNCTIONAL MATERIALS (2021)

Add to Collection

Article Engineering, Environmental

Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects

Zhen Yang et al.

Summary: The study developed double crosslinking injectable composite hydrogels for the treatment of tumor-related irregular bone defects, which combine both tumor therapy and bone regeneration functions. The composite hydrogel exhibited excellent photothermal effects, inhibiting tumor growth in mice and promoting new bone formation.

CHEMICAL ENGINEERING JOURNAL (2021)

Add to Collection

Review Oncology

Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells

M. C. Sanmartin et al.

Summary: Breast cancer, a common pathology in women, often leads to bone metastases with high mortality. Research shows that breast cancer cells prepare a pre-metastatic niche for colonization in the future. While the role of different cellular components in bone metastasis is well described, studying the changes in the microenvironment before tumor cells arrive is a novel field of research.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

The pathogenesis of bone metastasis in solid tumors: a review

Ivan Vicic et al.

Summary: Bone metastasis is a significant issue in the clinical course of tumor diseases, involving disruption of the physiological remodeling process by tumor cells via the same molecular mechanisms. The mechanisms involved in the early stages of bone metastasis and cancer cell dormancy are understudied, but their exploration may lead to potential therapeutic strategies.

CROATIAN MEDICAL JOURNAL (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Alendronate-functionalized hypoxia-responsive polymeric micelles for targeted therapy of bone metastatic prostate cancer

Mengmeng Long et al.

Summary: A bone-targeted and hypoxia-responsive polymeric micelle system was developed for effective treatment of bone metastatic prostate cancer, demonstrating significant inhibition of tumor growth in metastatic bone, promotion of osteoblast activity, relief of bone pain, and prolonged survival time.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Polymer Science

Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration

Xingchen Li et al.

Summary: The combination of hydrogels with nanoparticles of different dimensions provides excellent biocompatibility and adaptability for treating various forms of bone defects, showing great potential in bone regeneration applications.

MACROMOLECULAR RAPID COMMUNICATIONS (2021)

Add to Collection

Article Chemistry, Physical

Scaffold 3D-Printed from Metallic Nanoparticles-Containing Ink Simultaneously Eradicates Tumor and Repairs Tumor-Associated Bone Defects

Huimin Lin et al.

Summary: A bifunctional scaffold 3D-printed from nanoink containing metallic polydopamine nanoparticles (FeMg-NPs) is developed to eliminate tumor cells and repair bone defects associated with bone metastasis in breast cancer patients. This approach combines chemodynamic therapy with photothermal therapy to efficiently eradicate bone-metastatic tumors while promoting new bone formation.

SMALL METHODS (2021)

Add to Collection

Review Cell & Tissue Engineering

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Jinfeng Liao et al.

Summary: Bone tumors, especially osteosarcoma, present challenges in treatment as surgical resection often fails to completely remove the tumor, leading to high mortality rates. Recent developments in bifunctional biomaterials, such as hydrogels and 3D-printed scaffolds, offer potential new strategies for tumor therapy and bone regeneration.

BONE RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Xinxin Yuan et al.

Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.

THERANOSTICS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Metal-organic framework-based nanomaterials for biomedical applications

Shu Zhang et al.

CHINESE CHEMICAL LETTERS (2020)

Add to Collection

Article Engineering, Biomedical

Bone-targeting phospholipid polymers to solubilize the lipophilic anticancer drug

Akihisa Otaka et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Size-Tunable Strategies for a Tumor Targeted Drug Delivery System

Wenqi Yu et al.

ACS CENTRAL SCIENCE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer

Rui Liu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Review Engineering, Biomedical

Injectable Functional Biomaterials for Minimally Invasive Surgery

Maria Grazia Raucci et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer

Shao-bo Bai et al.

NANOMEDICINE (2020)

Add to Collection

Review Chemistry, Medicinal

Bone-Targeted Drug Delivery Systems and Strategies for Treatment of Bone Metastasis

Hidemasa Katsumi et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2020)

Add to Collection

Article Oncology

Bone health in cancer: ESMO Clinical Practice Guidelines

R. Coleman et al.

ANNALS OF ONCOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

Eunah Shin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Pharmacology & Pharmacy

The progress and perspective of nanoparticle-enabled tumor metastasis treatment

Wei Zhang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release

Rebecca Marie Dewhurst et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Add to Collection

Article Immunology

Chemokines in bone-metastatic breast cancer: Therapeutic opportunities

Yucheng Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Add to Collection

Article Medicine, General & Internal

Bone metastases

Robert E. Coleman et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Enhanced Cancer-targeted Drug Delivery Using Precoated Nanoparticles

Lu Yu et al.

NANO LETTERS (2020)

Add to Collection

Review Chemistry, Physical

3-D Cell Culture Systems in Bone Marrow Tissue and Organoid Engineering, and BM Phantoms as In Vitro Models of Hematological Cancer Therapeutics-A Review

Dasharatham Janagama et al.

MATERIALS (2020)

Add to Collection

Article Pharmacology & Pharmacy

3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Yan Wu et al.

PHARMACEUTICS (2020)

Add to Collection

Article Materials Science, Biomaterials

Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy

Yang Zhou et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Add to Collection

Article Materials Science, Biomaterials

Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer

Shih-Hong Chen et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Add to Collection

Review Physiology

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

John D. Martin et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

Add to Collection

Article Engineering, Biomedical

One stone with two birds: Phytic acid-capped platinum nanoparticles for targeted combination therapy of bone tumors

Zhengjie Zhou et al.

BIOMATERIALS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Linear Chimeric Triblock Molecules Self-Assembled Micelles with Controllably Transformable Property to Enhance Tumor Retention for Chemo-Photodynamic Therapy of Breast Cancer

Rui Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Add to Collection

Review Oncology

From latency to overt bone metastasis in breast cancer: potential for treatment and prevention

Fernando Salvador et al.

JOURNAL OF PATHOLOGY (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Bone-Targeted Nanoplatform Combining Zoledronate and Photothermal Therapy To Treat Breast Cancer Bone Metastasis

Wentong Sun et al.

ACS NANO (2019)

Add to Collection

Review Oncology

Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody

Roger von Moos et al.

CANCER TREATMENT REVIEWS (2019)

Add to Collection

Review Pharmacology & Pharmacy

Development and application of hyaluronic acid in tumor targeting drug delivery

Zhijian Luo et al.

ACTA PHARMACEUTICA SINICA B (2019)

Add to Collection

Article Multidisciplinary Sciences

Tailoring the component of protein corona via simple chemistry

Xiang Lu et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Nanoscience & Nanotechnology

A Carboxyl-Terminated Dendrimer Enables Osteolytic Lesion Targeting and Photothermal Ablation of Malignant Bone Tumors

Yang Yan et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Review Pharmacology & Pharmacy

Clinical and translational pharmacology of drugs for the prevention and treatment of bone metastases and cancer-induced bone loss

Maria Rita Dionisio et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Add to Collection

Article Oncology

Prognosis of renal cell carcinoma with bone metastases: Experience from a large cancer centre

F. Ruatta et al.

EUROPEAN JOURNAL OF CANCER (2019)

Add to Collection

Article Endocrinology & Metabolism

Tumor Cell Dormancy and Reactivation in Bone: Skeletal Biology and Therapeutic Opportunities

Niall M. Byrne et al.

JBMR PLUS (2019)

Add to Collection

Article Endocrinology & Metabolism

Bone as a Preferential Site for Metastasis

Miranda E. Sowder et al.

JBMR PLUS (2019)

Add to Collection

Review Oncology

Bone Metastasis: Find Your Niche and Fit in

Weijie Zhang et al.

TRENDS IN CANCER (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Ligand Size and Conformation Affect the Behavior of Nanoparticles Coated with in Vitro and in Vivo Protein Corona

Huajin Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Add to Collection

Review Engineering, Biomedical

Targeted drug delivery for tumor therapy inside the bone marrow

Chao-Feng Mu et al.

BIOMATERIALS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability

Wei Xiao et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Review Oncology

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Alison B. Shupp et al.

CANCERS (2018)

Add to Collection

Article Nanoscience & Nanotechnology

Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice

Yanzhi Liu et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Add to Collection

Article Pharmacology & Pharmacy

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Hua Wang et al.

PHARMACEUTICS (2018)

Add to Collection

Article Pharmacology & Pharmacy

The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system

Wei Xiao et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Review Endocrinology & Metabolism

Understanding the Bone in Cancer Metastasis

Jaime Fornetti et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Add to Collection

Article Nanoscience & Nanotechnology

Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone

Jinsong Liu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

Add to Collection

Article Endocrinology & Metabolism

Skeletal Complications and Mortality in Thyroid Cancer: A Population-Based Study

Palak Choksi et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Add to Collection

Article Medicine, General & Internal

HER2-positive breast cancer

Sibylle Loibl et al.

LANCET (2017)

Add to Collection

Review Pharmacology & Pharmacy

Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

Shu Yang et al.

PHARMACOLOGICAL RESEARCH (2017)

Add to Collection

Review Oncology

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

Rohit Sharma et al.

CELLULAR ONCOLOGY (2017)

Add to Collection

Review Engineering, Biomedical

Bisphosphonate-Functionalized Imaging Agents, Anti-Tumor Agents and Nanocarriers for Treatment of Bone Cancer

Robin A. Nadar et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Add to Collection

Article Engineering, Biomedical

Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue

Batzaya Byambaa et al.

ADVANCED HEALTHCARE MATERIALS (2017)

Add to Collection

Article Oncology

Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases

Michael H. Ross et al.

CANCER RESEARCH (2017)

Add to Collection

Article Pharmacology & Pharmacy

Synergistic dual-modified liposome improves targeting and therapeutic efficacy of bone metastasis from breast cancer

Xianzhu Ke et al.

DRUG DELIVERY (2017)

Add to Collection

Review Pharmacology & Pharmacy

Bone: A Fertile Soil for Cancer Metastasis

Thomas R. Coughlin et al.

CURRENT DRUG TARGETS (2017)

Add to Collection

Article Oncology

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

Helen Lee et al.

CLINICAL CANCER RESEARCH (2017)

Add to Collection

Review Oncology

Pre-metastatic niches: organ-specific homes for metastases

Hector Peinado et al.

NATURE REVIEWS CANCER (2017)

Add to Collection

Article Nanoscience & Nanotechnology

Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas

Yi Ju et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Add to Collection

Article Engineering, Biomedical

A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan

Xingli Cun et al.

ACTA BIOMATERIALIA (2016)

Add to Collection

Article Engineering, Biomedical

Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic

Kin Man Au et al.

BIOMATERIALS (2016)

Add to Collection

Article Oncology

Characteristics and Significance of the Pre-metastatic Niche

Yang Liu et al.

CANCER CELL (2016)

Add to Collection

Review Oncology

The influence of the pre-metastatic niche on breast cancer metastasis

Josie Ursini-Siegel et al.

CANCER LETTERS (2016)

Add to Collection

Review Allergy

Immediate-type hypersensitivity to polyethylene glycols: a review

E. Wenande et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Inhibition of bone loss with surface-modulated, drug-loaded nanoparticles in an intraosseous model of prostate cancer

Isaac M. Adjei et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Article Clinical Neurology

Evidence-Based Review and Survey of Expert Opinion of Reconstruction of Metastatic Spine Tumors

Farhaan Altaf et al.

SPINE (2016)

Add to Collection

Review Medicine, Research & Experimental

Bone site-specific delivery of siRNA

Xinli Liu

JOURNAL OF BIOMEDICAL RESEARCH (2016)

Add to Collection

Article Endocrinology & Metabolism

Liposomal Delivery of Dexamethasone Attenuates Prostate Cancer Bone Metastatic Tumor Growth In Vivo

Jan Kroon et al.

PROSTATE (2015)

Add to Collection

Review Orthopedics

Bone specific immunity and its impact on metastasis

Nikola Baschuk et al.

BONEKEY REPORTS (2015)

Add to Collection

Review Orthopedics

Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors

Yusuke Shiozawa et al.

BONEKEY REPORTS (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Cancer and bone: A complex complex

Marjolein van Driel et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

Add to Collection

Article Biochemical Research Methods

Bone-Targeted Acid-Sensitive Doxorubicin Conjugate Micelles as Potential Osteosarcoma Therapeutics

Stewart A. Low et al.

BIOCONJUGATE CHEMISTRY (2014)

Add to Collection

Review Pharmacology & Pharmacy

The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior

Huile Gao et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Add to Collection

Review Chemistry, Multidisciplinary

EPR: Evidence and fallacy

Joseph W. Nichols et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Add to Collection

Article Chemistry, Multidisciplinary

RGD peptide conjugated liposomal drug delivery system for enhance therapeutic efficacy in treating bone metastasis from prostate cancer

Fangfang Wang et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Add to Collection

Article Oncology

Bone metastasis, skeletal-related events, and mortality in lung cancer patients: A Danish population-based cohort study

Karynsa Cetin et al.

LUNG CANCER (2014)

Add to Collection

Article Multidisciplinary Sciences

Direct measurement of local oxygen concentration in the bone marrow of live animals

Joel A. Spencer et al.

NATURE (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

Makiko Ono et al.

SCIENCE SIGNALING (2014)

Add to Collection

Article Oncology

Modular tumor endoprostheses in surgical palliation of long-bone metastases: a reduction in tumor burden and a durable reconstruction

Marcel-Philipp Henrichs et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2014)

Add to Collection

Article Materials Science, Biomaterials

Paclitaxel-loaded polyphosphate nanoparticles: a potential strategy for bone cancer treatment

Evandro M. Alexandrino et al.

JOURNAL OF MATERIALS CHEMISTRY B (2014)

Add to Collection

Article Engineering, Biomedical

Poly(ethylene glycol)-paclitaxel-alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases

Keren Miller et al.

BIOMATERIALS (2013)

Add to Collection

Article Oncology

Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model

Qiqi Zhu et al.

CANCER CELL INTERNATIONAL (2013)

Add to Collection

Article Cell Biology

The perivascular niche regulates breast tumour dormancy

Cyrus M. Ghajar et al.

NATURE CELL BIOLOGY (2013)

Add to Collection

Review Biochemistry & Molecular Biology

PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery

Paola Milla et al.

CURRENT DRUG METABOLISM (2012)

Add to Collection

Article Cell & Tissue Engineering

The location and cellular composition of the hemopoietic stem cell niche

Sarah L. Ellis et al.

CYTOTHERAPY (2012)

Add to Collection

Article Oncology

Cytotoxicity of the new antimetabolite-bisphosphonate (5-FdU-alendronate) in comparison to standard therapeutics on breast and ovarian cancer cell lines in the ATP tumor chemosensitivity assay

Sarah Schott et al.

INVESTIGATIONAL NEW DRUGS (2012)

Add to Collection

Article Chemistry, Multidisciplinary

A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases

Mark J. Ernsting et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting

Gamal M. S. Zayed et al.

MACROMOLECULAR BIOSCIENCE (2012)

Add to Collection

Article Nanoscience & Nanotechnology

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Vikash P. Chauhan et al.

NATURE NANOTECHNOLOGY (2012)

Add to Collection

Review Endocrinology & Metabolism

Integrins and bone metastasis: Integrating tumor cell and stromal cell interactions

Jochen G. Schneider et al.

BONE (2011)

Add to Collection

Article Oncology

Survival in breast cancer patients with bone metastases and skeletal-related events: a population-based cohort study in Denmark (1999-2007)

Mellissa Yong et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

Add to Collection

Article Chemistry, Multidisciplinary

Hyaluronic Acid-Bound Letrozole Nanoparticles Restore Sensitivity to Letrozole-Resistant Xenograft Tumors in Mice

Hareesh B. Nair et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2011)

Add to Collection

Article Oncology

A Conjugate of Gemcitabine With Bisphosphonate (Gem/BP) Shows Potential as a Targeted Bone-Specific Therapeutic Agent in an Animal Model of Human Breast Cancer Bone Metastases

A. A. El-Mabhouh et al.

ONCOLOGY RESEARCH (2011)

Add to Collection

Article Endocrinology & Metabolism

Specific Binding and Mineralization of Calcified Surfaces by Small Peptides

Daniel K. Yarbrough et al.

CALCIFIED TISSUE INTERNATIONAL (2010)

Add to Collection

Article Oncology

Development of a novel poly bisphosphonate conjugate for treatment of skeletal metastasis and osteoporosis

Anders R. Holmberg et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2010)

Add to Collection

Article Urology & Nephrology

Skeletal Related Events, Bone Metastasis and Survival of Prostate Cancer: A Population Based Cohort Study in Denmark (1999 to 2007)

Mette Norgaard et al.

JOURNAL OF UROLOGY (2010)

Add to Collection

Article Oncology

GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

Yusuke Shiozawa et al.

NEOPLASIA (2010)

Add to Collection

Article Cell & Tissue Engineering

Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability

Hemant Sarin

VASCULAR CELL (2010)

Add to Collection

Article Chemistry, Medicinal

Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent

Jason R. Neale et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Add to Collection

Review Cell Biology

Migratory neighbors and distant invaders: tumor-associated niche cells

Jared Wels et al.

GENES & DEVELOPMENT (2008)

Add to Collection

Article Biochemical Research Methods

Osteotropic peptide that differentiates functional domains of the skeleton

Dong Wang et al.

BIOCONJUGATE CHEMISTRY (2007)

Add to Collection

Review Oncology

Bone marrow cells in the 'pre-metastatic niche': within bone and beyond

Rosandra N. Kaplan et al.

CANCER AND METASTASIS REVIEWS (2006)

Add to Collection

Article Oncology

Clinical features of metastatic bone disease and risk of skeletal morbidity

Robert E. Coleman

CLINICAL CANCER RESEARCH (2006)

Add to Collection

Review Pharmacology & Pharmacy

Bone-targeting macromolecular therapeutics

D Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

Add to Collection

Article Oncology

Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts

L Eikenes et al.

CANCER RESEARCH (2004)

Add to Collection

Article Immunology

Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications

H Maeda et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2003)

Add to Collection

Article Medicine, General & Internal

Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer.

S Braun et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.