Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 19, Issue 10, Pages 1217-1232Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17425247.2022.2093856
Keywords
Bone metastases; drug delivery; nanomedicine; nanotechnology; targeted therapies
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Funding
- National Natural Science Foundation of China [82174142]
- Natural Science Foundation of Guangdong Province [2021A1515410001]
- Zhuhai Xiangshan Talent Project [2021XSYC-01]
- Sichuan health research project [2022-216]
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Bone metastases are recognized as common metastases that affect patient quality of life and survival. Nanomedicine, as a new treatment strategy, shows great potential for the treatment of bone metastases.
Introduction Bone metastases have gradually been recognized as common metastases that affect patient quality of life and survival due to the increased incidence of primary tumors. However, there is still a lack of effective clinical treatment methods for bone metastases because of their particularity and complexity. Nanomedicine provides a new strategy for the treatment of bone metastases and shows great therapeutic potential. Thus, it is important to review the latest nanomedicine treatments for bone metastases. Areas covered This review introduces the mechanistic relationships of bone metastases and summarizes nanotechnology-based treatments of bone metastases according to targeting strategies. Expert opinion As we start to understand the mechanisms that enable bone metastases, we can better develop nanomedicine treatments. However, many of the mechanisms behind bone metastasis remain unclear. The application of nanomedicine shows promising anti-bone metastasis efficacy and helps to explore the pathogenesis of bone metastases. The optimized construction of nanomedicine according to bone metastatic properties is crucial to ensure the desired anti-bone metastasis efficacy and good biosafety. Therefore, the transition from bench to bedside still requires continued exploration.
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