Journal
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Volume 60, Issue -, Pages 7-18Publisher
ELSEVIER
DOI: 10.1016/j.euroneuro.2022.04.010
Keywords
Bipolar disorder; fMRI; Cluster analysis; Subgroups; Emotion regulation
Funding
- Research Fund of the Mental Health Services - Capital Region of Denmark
- Lundbeck Foundation Fellowship [R215-2015-4121]
Ask authors/readers for more resources
This study aims to assess the neural underpinnings of potential subgroups of bipolar disorder patients and found two distinct patient subgroups with different patterns of neural activity and relapse risk. Heightened amygdala reactivity was associated with increased risk of relapse.
Neuroimaging studies of bipolar disorder (BD) generally involve comparison with healthy controls (HC), which may mask neurobiological variability within the disorder. This study aims to assess the neural underpinnings of potential subgroups of BD patients based on functional activity in the emotion regulation network and its relation to illness characteristics and relapse risk. Eighty-seven remitted patients with recently diagnosed BD and 66 HC underwent functional magnetic resonance imaging (fMRI) while performing an emotion regulation task. Patients were re-assessed with clinical interviews after 16 ( +/- 5) months. Data-driven hierarchical cluster analysis was employed to investigate 'neuronal subgroups' of patients based on their neuronal activity in a pre-defined emotion regulation network. Relations between neuronal subgroups and illness characteristics and relapse rates were examined. Patients were allocated into two subgroups. Subgroup 1 (n = 62, 75%) was characterized by exaggerated bilateral amygdala reactivity but normal prefrontal and temporo-parietal activation. Subgroup 2 (n = 22, 25%) showed widespread hypo-activity within all emotion regulation regions. Both subgroups were less successful at down-regulating their emotions than HC ( F (2,146) = 5.33, p = .006, eta p 2 = .07). Patients in subgroup 2 had a history of more and longer mixed episodes (ps <=.01). Importantly, height-ened amygdala activity across all patients was associated with increased risk of relapse during a 16-month follow-up period (beta=3.36, 95% CI [1.49;550.35], N = 60, p = .03). The identified neu-ronal subgroups of patients with either amygdala hyper-activity or broad network hypo-activity during emotion regulation points to neurobiological heterogeneity among remitted patients with BD. Heightened amygdala reactivity may be a neuronal target for personalized treatments to prevent relapse. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available