Enantioselective Dual Catalysis of N-Heterocyclic Carbene and Hydrogen-Bond Donor Organocatalysts

N-heterocyclic carbene (NHC) catalysis has become a versatile catalysis strategy for building molecules via unique reaction modes. Dual catalytic processes using NHCs in combination with additional modulating agents such as another organocatalyst or transition-metal catalyst have also been studied. The clear selection of cocatalysts has led to enhanced reactivity, increased yields, and/or improved stereoselectivity. This minireview is to provide readers with a brief overview of the development and applications of NHC and hydrogen-bond donor for dual catalytic reactions.

Automated summary

N-heterocyclic carbene (NHC) catalysis is a versatile strategy for building molecules, and has been studied in combination with other catalytic agents to enhance reactivity and yield.