Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2022, Issue 38, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202200526
Keywords
CuAAC reactions; Pd-catalyzed couplings; Ru-mediated metathesis; Solid-phase synthesis; Transition-metal catalysis
Categories
Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT)
- Agencia Santafesina de Ciencia, Tecnica e Innovacion (ASACTEI)
- Universidad Nacional de Rosario, from Argentina
- CONICET
- ANPCyT
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Transition metal-catalyzed solid-phase reactions play an important role in synthetic biology and serve as a practical and fast strategy to meet the demands of organic chemistry.
Transition metal-catalyzed, C-C and C-N bond-forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid-phase chemistry soon made this type of reaction applicable to solid-supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid-phase CuAAC and ring-closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd-catalyzed reactions, such as Suzuki-Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid-phase transition metal-catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.
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