Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2022, Issue 31, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202200712
Keywords
alpha-Angelica lactone; alpha-Amino alkyl radicals; Lactams; Oxidation; Pyrrolidines
Categories
Funding
- Science and Engineering Research Board (SERB), New Delhi [EEQ/2016/000203, CRG/2021/005721]
- UGC, New Delhi
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An efficient protocol for synthesizing gamma-lactams from pyrrolidines and oxygen is reported. The strategy involves a two-step process of generating alpha-amino alkyl radicals followed by trapping with oxygen species. This method demonstrates good functional group acceptance and provides a direct approach to access gamma-lactams. The lactam derivatives were obtained in up to 98% yield.
Herein, we report an efficient protocol for the synthesis of gamma-lactams from pyrrolidines and oxygen. The strategy follows a two-step process involving an initial generation alpha-amino alkyl radicals from pyrrolidines and oxygen in presence of 4-dimethylaminopyridine (DMAP) followed by trapping of the radical with oxygen species. This protocol demonstrates good functional group acceptance and provides a direct method to access gamma-lactams. The lactam derivatives were obtained in up to 98 % yield.
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