Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 93, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2022.103874
Keywords
Occupational health; Pesticides; Metals; Cholinesterase inhibitors; Horticulture; Occupational exposures
Funding
- Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES) [001]
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This study compared flower farmers exposed to pesticides with unexposed individuals in terms of headache, irritability, and insomnia. The findings showed that flower farmers had a higher risk of experiencing headache and irritability, while the risk of insomnia was lower in the exposed group. Pesticide exposure had a significant effect on plasmatic and urinary manganese levels, as well as whole blood cholinesterase activity.
This work presents a frequency matched observational study comparing flower farmers exposed to pesticides and unexposed individuals as controls. All subjects were interviewed before plasma and urine collection. Manganese and Zinc were measured in theses samples by using dynamic reaction cell inductively coupled mass spectrometry. Cholinesterase activity was analyzed through spectrophotometry by using a modified version of the Ellman method. Seventy-eight percent of subjects reported occupational contact with pesticides, from which 37% reported exposure for over 9 years. Flower farms farmers had increased odds of having headache and irritability, respectively, by factors of 6.2 and 2.4 than the control subjects. While the odds of exposed subjects to have insomnia was smaller than control subjects by a factor of 0.34. Exposure to pesticides had a significant effect regarding the plasmatic plasma and urinary manganese levels and whole blood cholinesterase activity (p < 0.05). High levels of plasma and urinary manganese, as well as cholinesterase inhibition in whole blood, were evident in the flower farmers who participated in the study.
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