Related references
Note: Only part of the references are listed.Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations
Ioanna Mitrentsi et al.
MOLECULAR CELL (2022)
Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
Clemence Mooser et al.
NATURE COMMUNICATIONS (2020)
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Elaine Sanij et al.
NATURE COMMUNICATIONS (2020)
How to maintain the genome in nuclear space
Ioanna Mitrentsi et al.
CURRENT OPINION IN CELL BIOLOGY (2020)
JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage
Jeremie Fages et al.
PLOS GENETICS (2020)
Actin' between phase separated domains for heterochromatin repair
Chetan C. Rawal et al.
DNA REPAIR (2019)
RASSF1A is required for the maintenance of nuclear actin levels
Maria Chatzifrangkeskou et al.
EMBO JOURNAL (2019)
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
Sinan Kilic et al.
EMBO JOURNAL (2019)
Superresolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes
Tamara A. Potapova et al.
JOURNAL OF CELL BIOLOGY (2019)
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair
Lea M. Korsholm et al.
NUCLEIC ACIDS RESEARCH (2019)
Methylation Dynamics of RASSF1A and Its Impact on Cancer
Giorgio Malpeli et al.
CANCERS (2019)
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair
Aline Marnef et al.
GENES & DEVELOPMENT (2019)
Keeping ribosomal DNA intact: a repeating challenge
Daniel O. Warmerdam et al.
CHROMOSOME RESEARCH (2019)
RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis-an updated review
Fatemeh Dubois et al.
CELL DEATH & DISEASE (2019)
MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B
Dafni Eleftheria Pefani et al.
EMBO JOURNAL (2018)
Integrating the DNA damage and protein stress responses during cancer development and treatment
Vassilis G. Gorgoulis et al.
JOURNAL OF PATHOLOGY (2018)
Shieldin the ends for 53BP1
[Anonymous]
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
Mikael S. Lindstrom et al.
ONCOGENE (2018)
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
Thomas Clouaire et al.
MOLECULAR CELL (2018)
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ
Hind Ghezraoui et al.
NATURE (2018)
Chromatin and nucleosome dynamics in DNA damage and repair
Michael H. Hauer et al.
GENES & DEVELOPMENT (2017)
Chromatin modifiers and remodellers in DNA repair and signalling
Penny A. Jeggo et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Hong Xu et al.
NATURE COMMUNICATIONS (2017)
Ribosomal DNA copy number loss and sequence variation in cancer
Baoshan Xu et al.
PLOS GENETICS (2017)
Ribosomal DNA copy number amplification and loss in human cancers is linked to tumor genetic context, nucleolus activity, and proliferation
Meng Wang et al.
PLOS GENETICS (2017)
MST2-RASSF protein-protein interactions through SARAH domains
Goar Sanchez-Sanz et al.
BRIEFINGS IN BIOINFORMATICS (2016)
Coexisting Liquid Phases Underlie Nucleolar Subcompartments
Marina Feric et al.
CELL (2016)
Hippo pathway and protection of genome stability in response to DNA damage
Dafni E. Pefani et al.
FEBS JOURNAL (2016)
TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation
Dafni-Eleftheria Pefani et al.
MOLECULAR CELL (2016)
Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin
Katerina Tsouroula et al.
MOLECULAR CELL (2016)
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Rebecca Kring Hansen et al.
NATURE CELL BIOLOGY (2016)
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Petra Schwertman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats
Daniel O. Warmerdam et al.
CELL REPORTS (2016)
Clinical utility of RASSF1A methylation in human malignancies
A. M. Grawenda et al.
BRITISH JOURNAL OF CANCER (2015)
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage
Marjolein van Sluis et al.
GENES & DEVELOPMENT (2015)
Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response
Ralph E. Kleiner et al.
NATURE CHEMICAL BIOLOGY (2015)
Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes
John G. Gibbons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Rohit Prakash et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition
Shane M. Harding et al.
CELL REPORTS (2015)
ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX
Robert A. Baldock et al.
CELL REPORTS (2015)
Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1
Lin Feng et al.
CELL DISCOVERY (2015)
The RASSF1A Tumor Suppressor Regulates XPA-Mediated DNA Repair
Howard Donninger et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks
James M. Daley et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2
Dafni-Eleftheria Pefani et al.
NATURE CELL BIOLOGY (2014)
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Dorthe H. Larsen et al.
NATURE CELL BIOLOGY (2014)
Activation of DNA Damage Response Signaling by Condensed Chromatin
Rebecca C. Burgess et al.
CELL REPORTS (2014)
The shared genomic architecture of human nucleolar organizer regions
Ioanna Floutsakou et al.
GENOME RESEARCH (2013)
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
J. Ross Chapman et al.
MOLECULAR CELL (2013)
Spatial Dynamics of Chromosome Translocations in Living Cells
Vassilis Roukos et al.
SCIENCE (2013)
Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair
Irene Chiolo et al.
CELL (2011)
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin
Burkhard Jakob et al.
NUCLEIC ACIDS RESEARCH (2011)
53BP1 promotes ATM activity through direct interactions with the MRN complex
Ji-Hoon Lee et al.
EMBO JOURNAL (2010)
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
Angela T. Noon et al.
NATURE CELL BIOLOGY (2010)
Functional importance of RASSF1A microtubule localization and polymorphisms
M. El-Kalla et al.
ONCOGENE (2010)
Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity
Satoru Ide et al.
SCIENCE (2010)
Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer
Dawn M. Stults et al.
CANCER RESEARCH (2009)
ATM Regulates a RASSF1A-Dependent DNA Damage Response
Garth Hamilton et al.
CURRENT BIOLOGY (2009)
The DNA-damage response in human biology and disease
Stephen P. Jackson et al.
NATURE (2009)
Genomic architecture and inheritance of human ribosomal RNA gene clusters
Dawn M. Stults et al.
GENOME RESEARCH (2008)
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Niels Mailand et al.
CELL (2007)
RASSRA elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the P73 tumor suppressor protein
David Matallanas et al.
MOLECULAR CELL (2007)
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Michael Kruhlak et al.
NATURE (2007)
Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest
R Rong et al.
ONCOGENE (2004)
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
RA DiTullio et al.
NATURE CELL BIOLOGY (2002)