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A. Yalcin et al.
CELL DEATH & DISEASE (2014)
Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells
Laura Brunelli et al.
ONCOTARGET (2014)
Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRASG12D-driven lung tumors
Jessie Yanxiang Guo et al.
AUTOPHAGY (2013)
Resistance to Irreversible EGF Receptor Tyrosine Kinase Inhibitors through a Multistep Mechanism Involving the IGF1R Pathway
Alexis B. Cortot et al.
CANCER RESEARCH (2013)
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert et al.
CELL METABOLISM (2013)
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
Laura Soucek et al.
GENES & DEVELOPMENT (2013)
Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin
Laurent Schwartz et al.
INVESTIGATIONAL NEW DRUGS (2013)
Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-small Cell Lung Cancer via Promotion of E2F1, Cyclin D1, and Cyclin E1 Expression
Long Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
Zaheed Husain et al.
JOURNAL OF IMMUNOLOGY (2013)
Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
Mohd Askandar Iqbal et al.
MOLECULAR CANCER (2013)
Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Ruiting Lin et al.
MOLECULAR CELL (2013)
Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Lei Lv et al.
MOLECULAR CELL (2013)
Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle
Mahesh Saqcena et al.
PLOS ONE (2013)
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Jurre J. Kamphorst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
ATP citrate lyase knockdown impacts cancer stem cells in vitro
J-I Hanai et al.
CELL DEATH & DISEASE (2013)
Fulfilling the metabolic requirements for cell proliferation
Salvador Moncada et al.
BIOCHEMICAL JOURNAL (2012)
Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells
Vicky Goler-Baron et al.
BIOCHEMICAL PHARMACOLOGY (2012)
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
Mariia O. Yuneva et al.
CELL METABOLISM (2012)
K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
Yumin Hu et al.
CELL RESEARCH (2012)
Correction of Metabolic Acidosis with Potassium Citrate in Renal Transplant Patients and its Effect on Bone Quality
Astrid Starke et al.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)
Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth, Angiogenesis and Metastasis
Suveera Dhup et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
From tumor prevention to therapy: Empowering p53 to fight back
Christian Frezza et al.
DRUG RESISTANCE UPDATES (2012)
Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
Roel H. Wilting et al.
DRUG RESISTANCE UPDATES (2012)
Availability, not respiratory capacity governs oxygen consumption of solid tumors
Peter Vaupel et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)
Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutation
Santanu Dasgupta et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways
Jun-ichi Hanai et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome
Nathan T. Ihle et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)
Identification of Isocitrate Dehydrogenase 1 as a Potential Diagnostic and Prognostic Biomarker for Non-small Cell Lung Cancer by Proteomic Analysis
Fengwei Tan et al.
MOLECULAR & CELLULAR PROTEOMICS (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang et al.
NATURE CELL BIOLOGY (2012)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Dimitrios Anastasiou et al.
NATURE CHEMICAL BIOLOGY (2012)
Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin
Mohd Askandar Iqbal et al.
PLOS ONE (2012)
HER2 Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in EGFR-Mutant Lung Cancers That Lack the Second-Site EGFRT790M Mutation
Ken Takezawa et al.
CANCER DISCOVERY (2012)
Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
Nadine Rohwer et al.
DRUG RESISTANCE UPDATES (2011)
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
Sybille Mazurek
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
Lei Lv et al.
MOLECULAR CELL (2011)
New driver mutations in non-small-cell lung cancer
William Pao et al.
LANCET ONCOLOGY (2011)
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
Daniela Gaglio et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Weiwei Yang et al.
NATURE (2011)
Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression
Gian Kayser et al.
PATHOLOGY (2011)
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells
Sergio L. Colombo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
Marco Demaria et al.
AGING-US (2010)
Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
Stephen Y. Lai et al.
DRUG RESISTANCE UPDATES (2010)
Clinical Relevance of KRAS in Human Cancers
Sylwia Jancik et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David et al.
NATURE (2010)
PTEN and the PI3-Kinase Pathway in Cancer
Nader Chalhoub et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2009)
The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer
Scott A. Kono et al.
DRUG RESISTANCE UPDATES (2009)
HIF-1 alpha Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms
Alvaro Marin-Hernandez et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2009)
Hypoxia Enhances Sphingosine Kinase 2 Activity and Provokes Sphingosine-1-Phosphate-Mediated Chemoresistance in A549 Lung Cancer Cells
Steffen E. Schnitzer et al.
MOLECULAR CANCER RESEARCH (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Taro Hitosugi et al.
SCIENCE SIGNALING (2009)
ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer
Toshiro Migita et al.
CANCER RESEARCH (2008)
Brick by brick: metabolism and tumor cell growth
Ralph J. DeBerardinis et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2008)
Mitochondrial oxidative phosphorylation is regulated by fructose 1,6-bisphosphate -: A possible role in Crabtree effect induction?
Rodrigo Diaz-Ruiz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
Brian Clem et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Nicholas C. Denko
NATURE REVIEWS CANCER (2008)
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
Sizhi Paul Gao et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
Esther Conde et al.
HUMAN PATHOLOGY (2007)
A pivotal role for p53: balancing aerobic respiration and glycolysis
Wenzhe Ma et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
Kirsty S. Hewitson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
ATP citrate lyase inhibition can suppress tumor cell growth
G Hatzivassiliou et al.
CANCER CELL (2005)
ATP citrate lyase is an important component of cell growth and transformation
DE Bauer et al.
ONCOGENE (2005)
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
MI Koukourakis et al.
BRITISH JOURNAL OF CANCER (2003)
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
DC Berwick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression
D D'Arcangelo et al.
CIRCULATION RESEARCH (2000)
Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins
R Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)