4.4 Review

Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Urinary deoxynivalenol as a biomarker of exposure in different age, life stage and dietary practice population groups

Gunnar Sundstol Eriksen et al.

Summary: Norwegians are exposed to deoxynivalenol (DON) in similar levels as reported from other countries, with children having higher exposure than adults. Urinary DON concentration as a tool for estimating exposure at population level is effective, but uncertainties exist at the individual level.

ENVIRONMENT INTERNATIONAL (2021)

Article Food Science & Technology

Species Differences in in vitro and Estimated in vivo Kinetics for Intestinal Microbiota Mediated Metabolism of Acetyl-deoxynivalenols

Jing Jin et al.

Summary: The study reveals interspecies differences in the deacetylation of acetylated DONs, but assuming complete intestinal deconjugation is an adequate approach for risk assessment.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Article Food Science & Technology

Occurrence of Fusarium Mycotoxins and Their Modified Forms in Forage Maize Cultivars

Tim Birr et al.

Summary: The study found that forage maize in Northern Germany is often contaminated by multiple Fusarium mycotoxins, with high levels of DON and ZEN and the presence of their modified forms. The results demonstrate the significant contribution of modified mycotoxins to overall mycotoxin contamination in forage maize, highlighting the importance of including analysis of modified mycotoxins in future monitoring programs.

TOXINS (2021)

Review Toxicology

Hypoxia, oxidative stress, and immune evasion: a trinity of the trichothecenes T-2 toxin and deoxynivalenol (DON)

Li You et al.

Summary: T-2 toxin and DON, as type A and B trichothecenes, widely occur as pollutants in food and crops, causing toxicities primarily based on oxidative stress mechanisms. Mitochondria play a significant role in apoptosis induced by oxidative stress from these toxins. Hypoxia and immune evasion are closely related to oxidative stress in this context.

ARCHIVES OF TOXICOLOGY (2021)

Article Food Science & Technology

Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans

Ying Deng et al.

Summary: This study systematically evaluated the characteristics of human DON and DON-3G biomarkers, revealing that children and adolescents have higher levels of DON exposure compared to adults, while the elderly have the lowest levels, suggesting that young people, including children, face greater health risks. Pregnant women may transmit DON through the placental barrier from mothers, potentially inhibiting fetal growth and immune function. The vegetarian population is at higher risk of exposure to DON and DON-3G due to their greater consumption of vegetables and cereals.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

Review Food Science & Technology

Biomarkers of Deoxynivalenol Toxicity in Chickens with Special Emphasis on Metabolic and Welfare Parameters

Insaf Riahi et al.

Summary: Long-term exposure to DON can result in impaired growth performance and health status of chickens. Biomarkers of DON exposure in chickens include DON-3 sulphate, while markers of effect can manifest as impaired productive parameters, intestinal morphology changes, and altered immune responses.

TOXINS (2021)

Article Agriculture, Dairy & Animal Science

Occurrence of Aflatoxin B1, deoxynivalenol and zearalenone in feeds in China during 2018-2020

Ling Zhao et al.

Summary: This study reveals that feeds in China were contaminated with AFB(1), DON, and ZEN over the past 3 years. More than 81.5% of feed ingredients and 95.7% of complete feeds were co-contaminated with various combinations of these mycotoxins.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2021)

Review Food Science & Technology

A systematic review of plant-conjugated masked mycotoxins: Occurrence, toxicology, and metabolism

Zhiqi Zhang et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Review Food Science & Technology

Deoxynivalenol: Masked forms, fate during food processing, and potential biological remedies

Hongyan Guo et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2020)

Review Fisheries

Mycotoxins in aquaculture: feed and food

Rui A. Goncalves et al.

REVIEWS IN AQUACULTURE (2020)

Review Biotechnology & Applied Microbiology

Fusarium head blight in wheat: contemporary status and molecular approaches

Mohd. Kamran Khan et al.

3 BIOTECH (2020)

Article Food Science & Technology

Enzymatic degradation of deoxynivalenol by a novel bacterium, Pelagibacterium halotolerans ANSP101

Jing Zhang et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Review Food Science & Technology

The neurotoxicity of trichothecenes T-2 toxin and deoxynivalenol (DON): Current status and future perspectives

Jiajia Zhang et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Toxicology

The Fusarium metabolite culmorin suppresses the in vitro glucuronidation of deoxynivalenol

Lydia Woelflingseder et al.

ARCHIVES OF TOXICOLOGY (2019)

Article Agriculture, Dairy & Animal Science

Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells

Junmei Wang et al.

JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION (2019)

Article Biochemistry & Molecular Biology

Deoxynivalenol Detoxification in Transgenic Wheat Confers Resistance to Fusarium Head Blight and Crown Rot Diseases

Giulia Mandala et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2019)

Article Biotechnology & Applied Microbiology

The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway

Jason Carere et al.

MICROBIAL BIOTECHNOLOGY (2018)

Article Food Science & Technology

Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse

James J. Pestka et al.

TOXINS (2017)

Review Toxicology

Trichothecenes: immunomodulatory effects, mechanisms, and anti-cancer potential

Qinghua Wu et al.

ARCHIVES OF TOXICOLOGY (2017)

Review Toxicology

Toxicology of deoxynivalenol and its acetylated and modified forms

Delphine Payros et al.

ARCHIVES OF TOXICOLOGY (2016)

Article Multidisciplinary Sciences

Microbial biotransformation of DON: molecular basis for reduced toxicity

Alix Pierron et al.

SCIENTIFIC REPORTS (2016)

Article Biochemical Research Methods

Critical evaluation of indirect methods for the determination of deoxynivalenol and its conjugated forms in cereals

Alexandra Malachova et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2015)

Article Food Science & Technology

Toxicology of 3-epi-deoxynivalenol, a deoxynivalenol-transformation product by Devosia mutans 17-2-E-8

Jian Wei He et al.

FOOD AND CHEMICAL TOXICOLOGY (2015)

Article Agriculture, Multidisciplinary

Nucleophilic Addition of Thiols to Deoxynivalenol

Ana Stanic et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Article Agriculture, Multidisciplinary

Oral Bioavailability, Hydrolysis, and Comparative Toxicokinetics of 3-Acetyldeoxynivalenol and 15-Acetyldeoxynivalenol in Broiler Chickens and Pigs

Nathan Broekaert et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

Article Food Science & Technology

Murine Anorectic Response to Deoxynivalenol (Vomitoxin) Is Sex-Dependent

Erica S. Clark et al.

TOXINS (2015)

Article Food Science & Technology

Metabolism of Deoxynivalenol and Deepoxy-Deoxynivalenol in Broiler Chickens, Pullets, Roosters and Turkeys

Heidi E. Schwartz-Zimmermann et al.

TOXINS (2015)

Article Biochemical Research Methods

Deoxynivalenol (DON) sulfonates as major DON metabolites in rats: from identification to biomarker method development, validation and application

Heidi E. Schwartz-Zimmermann et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Structural basis for the inhibition of the eukaryotic ribosome

Nicolas Garreau de Loubresse et al.

NATURE (2014)

Article Toxicology

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs

Veronika Nagl et al.

TOXICOLOGY LETTERS (2014)

Article Biotechnology & Applied Microbiology

Bacterial Cytochrome P450 System Catabolizing the Fusarium Toxin Deoxynivalenol

Michihiro Ito et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Article Biotechnology & Applied Microbiology

The Human Fecal Microbiota Metabolizes Deoxynivalenol and Deoxynivalenol-3-Glucoside and May Be Responsible for Urinary Deepoxy-Deoxynivalenol

Silvia W. Gratz et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)

Article Environmental Sciences

Multimycotoxin analysis in urines to assess infant exposure: A case study in Cameroon

Emmanuel Njumbe Ediage et al.

ENVIRONMENT INTERNATIONAL (2013)

Article Agriculture, Multidisciplinary

Enzyme-Assisted Synthesis and Structural Characterization of the 3-, 8-, and 15-Glucuronides of Deoxynivalenol

Silvio Uhlig et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Article Food Science & Technology

Digestibility and absorption of deoxynivalenol-3-β-glucoside in in vitro models

M. De Nijs et al.

WORLD MYCOTOXIN JOURNAL (2012)

Article Food Science & Technology

Simultaneous determination of masked forms of deoxynivalenol and zearalenone after oral dosing in rats by LC-MS/MS

A. Versilovskis et al.

WORLD MYCOTOXIN JOURNAL (2012)

Article Food Science & Technology

Assessment of deoxynivalenol metabolite profiles in UK adults

Paul C. Turner et al.

FOOD AND CHEMICAL TOXICOLOGY (2011)

Article Toxicology

Hydrolytic fate of deoxynivalenol-3-glucoside during digestion

Franz Berthiller et al.

TOXICOLOGY LETTERS (2011)

Article Agriculture, Multidisciplinary

Determinants of Urinary Deoxynivalenol and De-epoxy Deoxynivalenol in Male Farmers from Normandy, France

Paul C. Turner et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Transcriptome Analysis of the Barley-Deoxynivalenol Interaction: Evidence for a Role of Glutathione in Deoxynivalenol Detoxification

Stephanie A. Gardiner et al.

MOLECULAR PLANT-MICROBE INTERACTIONS (2010)

Article Food Science & Technology

Degradation of trichothecene mycotoxins by chicken intestinal microbes

J. Christopher Young et al.

FOOD AND CHEMICAL TOXICOLOGY (2007)

Article Biotechnology & Applied Microbiology

A novel regulatory gene, Tri10, controls trichothecene toxin production and gene expression

AG Tag et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2001)