4.7 Review

Repurposing of parenterally administered active substances used to treat pain both systemically and locally

Related references

Note: Only part of the references are listed.
Review Anesthesiology

Molecular Modification of Transient Receptor Potential Canonical 6 Channels Modulates Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia

Brian M. Ilfeld et al.

Summary: The study demonstrates that overexpressing a nonconducting TRPC6 channel can partially ameliorate the imbalance of calcium and sodium in muscle caused by RYR1 variants, prolonging survival time during halothane exposure, but is not sufficient to prevent the lethal effects of exposure to volatile anesthetic malignant hyperthermia-triggering agents.

ANESTHESIOLOGY (2021)

Article Pharmacology & Pharmacy

Preparation and characterization of bupivacaine multivesicular liposome: A QbD study about the effects of formulation and process on critical quality attributes

Bohong Lu et al.

Summary: This study extends QbD principles to liposomal products with a hydrophilic API, demonstrating the feasibility and advantages of the concept for multivesicular liposome-based systems. The preparation process significantly affects the particle size and drug encapsulation efficiency of liposomes, with material attributes and processing parameters playing key roles. Risk assessment was used to monitor factors affecting encapsulation rate and particle size.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Anesthesiology

The analgesic efficacy of liposomal bupivacaine compared with bupivacaine hydrochloride for the prevention of postoperative pain: a systematic review and meta-analysis with trial sequential analysis

Hanns-Christian Dinges et al.

Summary: Liposomal bupivacaine showed significantly lower postoperative pain scores and morphine consumption compared to bupivacaine hydrochloride at 24 hours postoperatively, but not at 72 hours. Despite statistical significance, the effect was small and not clinically relevant. It was consistent across all studies, indicating independence from the application modality.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2021)

Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Surgery

The Efficacy of Liposomal Bupivacaine for Opioid and Pain Reduction: A Systematic Review of Randomized Clinical Trials

Yisi D. Ji et al.

Summary: The majority of RCTs did not support the efficacy of liposomal bupivacaine for superior postoperative pain control or reduced opioid consumption. Financial conflicts of interest among authors may lead to biased reporting of trial results.

JOURNAL OF SURGICAL RESEARCH (2021)

Review Clinical Neurology

Exparel for Postoperative Pain Management: a Comprehensive Review

Alan David Kaye et al.

CURRENT PAIN AND HEADACHE REPORTS (2020)

Review Pharmacology & Pharmacy

Clinically established biodegradable long acting injectables: An industry perspective

Christian Isalomboto Nkanga et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Article Public, Environmental & Occupational Health

Access to Pain Management as a Human Right

Frank Brennan et al.

AMERICAN JOURNAL OF PUBLIC HEALTH (2019)

Article Pharmacology & Pharmacy

Development of a novel one-step production system for injectable liposomes under GMP

Ryo Araki et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2018)

Review Pharmacology & Pharmacy

Recent advances in intra-articular drug delivery systems for osteoarthritis therapy

Pierre Maudens et al.

DRUG DISCOVERY TODAY (2018)

Article Pharmacology & Pharmacy

In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release

Chan-Jung Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Review Medicine, Research & Experimental

Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis

L. Dinesh Kumar et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Article Rheumatology

Glucocorticoids and Rheumatoid Arthritis

Joana Fonseca Ferreira et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2016)

Review Ophthalmology

Fluocinolone acetonide (ILUVIEN®) micro-implant for chronic diabetic macular edema

G. Soubrane et al.

JOURNAL FRANCAIS D OPHTALMOLOGIE (2015)

Review Anesthesiology

Lipid emulsion therapy: non-nutritive uses of lipid emulsions in anaesthesia and intensive care

M. Buys et al.

SOUTHERN AFRICAN JOURNAL OF ANAESTHESIA AND ANALGESIA (2015)

Review Pharmacology & Pharmacy

Safety of liposome extended-release bupivacaine for postoperative pain control

Juan Portillo et al.

FRONTIERS IN PHARMACOLOGY (2014)

Review Anesthesiology

Liposomal bupivacaine and clinical outcomes

Yi Cai Isaac Tong et al.

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2014)

Article Ophthalmology

A Comparison Between the Fluocinolone Acetonide (Retisert) and Dexamethasone (Ozurdex) Intravitreal Implants in Uveitis

Cheryl A. Arcinue et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2013)

Review Multidisciplinary Sciences

Pharmaceutical Point of View on Parenteral Nutrition

M. Stawny et al.

SCIENTIFIC WORLD JOURNAL (2013)

Editorial Material Allergy

A case of anaphylaxis caused by macrogol 3350 after injection of a corticosteroid

Alicia Bordere et al.

CONTACT DERMATITIS (2012)

Article Orthopedics

Anaphylaxis at image-guided epidural pain block secondary to corticosteroid compound

Deirdre E. Moran et al.

SKELETAL RADIOLOGY (2012)

Review Pharmacology & Pharmacy

Liposome Technology for Industrial Purposes

Andreas Wagner et al.

JOURNAL OF DRUG DELIVERY (2011)

Review Pharmacology & Pharmacy

Injectable Lipid Emulsions-Advancements, Opportunities and Challenges

Ketan Hippalgaonkar et al.

AAPS PHARMSCITECH (2010)

Article Pharmacology & Pharmacy

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

J. A. DiMasi et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)

Article Ophthalmology

Retinal toxicity of intravitreal Kenalog in albino rabbits

Yaron Lang et al.

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES (2007)

Review Pharmacology & Pharmacy

Intraarticular drug delivery in osteoarthritis

N Gerwin et al.

ADVANCED DRUG DELIVERY REVIEWS (2006)

Review Anesthesiology

Propofol - The challenges of formulation

MT Baker et al.

ANESTHESIOLOGY (2005)

Review Biochemistry & Molecular Biology

A lipid based depot (DepoFoam® technology) for sustained release drug delivery

S Mantripragada

PROGRESS IN LIPID RESEARCH (2002)

Article Anesthesiology

Cost-effectiveness of analgesia after Caesarean section. A comparison of intrathecal morphine and epidural PCA

M Vercauteren et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2002)