Journal
DIABETES RESEARCH AND CLINICAL PRACTICE
Volume 190, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2022.109987
Keywords
Type 1 diabetes; microRNAs; Diabetic complications; Cardiovascular diseases; Hypertension; Albuminuria; Diabetic nephropathy; Diabetic kidney disease; TGF-beta 1
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Funding
- Cassa di Risparmio di Torino (CRT)
- European Foundation for the Study of Diabetes (EFSD)
- Turin University
- Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Universita e della Ricerca-MIUR) [D15D18000410001]
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This study found an inverse association between miR-145-5p levels and albuminuria in patients with type 1 diabetes, and this relationship was mediated by systemic hypertension.
Aims: To investigate whether serum miR-145-5p levels were associated with micro-macrovascular chronic complications in patients with type 1 diabetes (DM1). Methods: A nested case-control study from the EURODIAB Prospective Complications Study was performed. Cases (n = 289) had one or more complications of diabetes, whereas controls (n = 153) did not have any complication. We measured miR-145-5p levels by qPCR and investigated the association with diabetes complications. Results: Mean miR-145-5p levels were significantly lower in cases with microangiopathy [2.12 (0.86-4.94)] compared to controls [3.15 (1.21-7.36), P < 0.05] even after adjustment for age, gender, and diabetes duration. In logistic regression analysis, miR-145-5p levels in the lowest tertile were associated with an over three-fold increased odds ratio (OR) of albuminuria [3.22 (1.17-8.81)], independently of both demographic and diabetes-related factors. In addition, mir145-5p levels in the lowest tertile were independently and inversely associated with arterial hypertension [1.96 (1.08-3.56)] and hypertension was the mediator of the relationship between miR-145-5p and albuminuria. Conclusions: In this large cohort of DM1 patients, we found an inverse association between miR-145-5p and albuminuria that was mediated by systemic hypertension.
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