It takes a lot of nerve to form the lung alveolus

Autonomic nerves innervate the lungs, but how these nerves guide lung development remains unclear. In this issue of Developmental Cell, Zhang et al. reveal that myofibroblasts and developing nerves cross -communi-cate through neurotrophins and neurotransmitters to drive alveologenesi???and that planar cell polarity signaling is critical to this process.

Automated summary

This article discusses the guidance role of autonomic nerves in lung development, revealing the communication between myofibroblasts and developing nerves through neurotrophins and neurotransmitters to drive alveologenesis, with planar cell polarity signaling playing a critical role.