4.7 Article

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N6-methyladenosine

Related references

Note: Only part of the references are listed.
Article Cell Biology

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells

Yabing Chen et al.

Summary: The study reveals a negative association between m(6)A modification and autophagy in Leydig cells during testosterone synthesis. The regulation of METTL14, ALKBH5, and m(6)A influences AMP-activated protein kinase activity and subsequent autophagy in Leydig cells. Human chorionic gonadotropin treatment modulates m(6)A modification by upregulating ALKBH5 and decreasing METTL14, affecting the synthesis of testosterone.

AUTOPHAGY (2021)

Article Multidisciplinary Sciences

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Runping Fang et al.

Summary: In this study, it was revealed that YTHDF2 overexpression is associated with poor prognosis in glioma patients due to EGFR-induced protein stabilization, leading to reduced cholesterol homeostasis and promoting GBM tumorigenesis through an RNA m6A methylation dependent mechanism.

NATURE COMMUNICATIONS (2021)

Review Oncology

Diffuse Glioma Heterogeneity and Its Therapeutic Implications

James G. Nicholson et al.

Summary: Diffuse gliomas are characterized by high levels of genetic, epigenetic, and environmental heterogeneity, leading to extreme phenotypic heterogeneity at the cellular level and resistance to various therapies. The intratumoral heterogeneity and malignant cell state plasticity in gliomas pose significant challenges to the development of novel targeted therapies.

CANCER DISCOVERY (2021)

Article Biochemical Research Methods

Quantitative analysis of m6A RNA modification by LC-MS

Lavina Mathur et al.

Summary: The N6-adenosine methylation (m6A) of messenger RNA (mRNA) is crucial for gene expression regulation. This protocol outlines a method for quantitating adenosine and m6A levels in cellular mRNA through nucleoside digestion and liquid chromatography mass spectrometry. For more details, refer to Cho et al. (2021).

STAR PROTOCOLS (2021)

Review Neurosciences

The m(6)A epitranscriptome: transcriptome plasticity in brain development and function

Ido Livneh et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Review Oncology

Role of RNA modifications in cancer

Isaia Barbieri et al.

NATURE REVIEWS CANCER (2020)

Review Oncology

The Critical Role of RNA m6A Methylation in Cancer

Qing Lan et al.

CANCER RESEARCH (2019)

Article Immunology

Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma

Stephen C. Mack et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Review Cell Biology

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

Ryan C. Gimple et al.

GENES & DEVELOPMENT (2019)

Article Multidisciplinary Sciences

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

Daniel A. Kuppers et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter

Dian-gang Chen et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Letter Biotechnology & Applied Microbiology

Toil enables reproducible, open source, big biomedical data analyses

John Vivian et al.

NATURE BIOTECHNOLOGY (2017)

Review Oncology

Expanding perspectives on the significance of mitophagy in cancer

Lauren E. Drake et al.

SEMINARS IN CANCER BIOLOGY (2017)

Article Cell Biology

PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation

Justin R. Sysol et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

Article Oncology

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

Sameer Agnihotri et al.

CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

A Positive Feed-forward Loop Associating EGR1 and PDGFA Promotes Proliferation and Self-renewal in Glioblastoma Stem Cells

Nathalie Sakakini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

Ping Wang et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Benjamin Richter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

Andrew S. Moore et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Oncology

Mitophagy and cancer

Aparajita H. Chourasia et al.

CANCER & METABOLISM (2015)

Review Cell & Tissue Engineering

Evolution of the Cancer Stem Cell Model

Antonija Kreso et al.

CELL STEM CELL (2014)

Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

Review Cell Biology

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

Kate D. Meyer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

The Somatic Genomic Landscape of Glioblastoma

Cameron W. Brennan et al.

Review Biochemistry & Molecular Biology

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

Jian Chen et al.

Article Immunology

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

Petra Hamerlik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2012)

Review Medicine, General & Internal

PDGF and PDGF receptors in glioma

Inga Nazarenko et al.

UPSALA JOURNAL OF MEDICAL SCIENCES (2012)

Article Biochemical Research Methods

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

Yifang Hu et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2009)

Article Transplantation

Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells

Danuta Sabuda-Widemann et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

Article Medicine, General & Internal

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors

IK Mellinghoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)