Journal
DERMATOLOGIC THERAPY
Volume 35, Issue 8, Pages -Publisher
WILEY
DOI: 10.1111/dth.15633
Keywords
classification; losartan; mycophenolic acid; stiff skin syndrome; therapeutics
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Funding
- Science and Technology Planning Project of Guangzhou [202103000001]
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Stiff skin syndrome (SSS) is a rare disorder characterized by skin induration and limited joint mobility. Combination therapy with medications and rehabilitation training can effectively retard the progression of SSS.
Stiff skin syndrome (SSS) is a rare disorder characterized by skin induration and limited joint mobility in the absence of visceral, musculoskeletal, vascular, or immunologic abnormalities. Distinctive subsets of SSS could be distinguished by various manifestation and mechanism, which accounts for the high heterogeneity in SSS cases. Although rehabilitation training remains the mainstay of management, rising medications has drawn awareness in recent years, owing to the potential efficacy. Nevertheless, experience was limited, especially in widespread SSS. We report on a 5-year-old girl with widespread SSS, whose lesion stopped progressing after combination therapy by mycophenolic acid (MPA) and losartan (LST) in addition to rehabilitation exercise. Despite limited experience, a combined therapy of MPA and LST seems to be effective in retarding progression of widespread SSS.
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