The impact of adipokines on vascular networks in adipose tissue

Adipose tissue (AT) is a highly active and plastic endocrine organ. It secretes numerous soluble molecules known as adipokines, which act locally to AT control the remodel and homeostasis or exert pleiotropic functions in different peripheral organs. Aberrant production or loss of certain adipokines contributes to AT dysfunction associated with metabolic disorders, including obesity. The AT plasticity is strictly related to tissue vasculari-zation. Angiogenesis supports the AT expansion, while regression of blood vessels is associated with AT hypoxia, which in turn mediates tissue inflammation, fibrosis and metabolic dysfunction. Several adipokines can regulate endothelial cell functions and are endowed with either pro-or anti-angiogenic properties. Here we address the role of adipokines in the regulation of angiogenesis. A better understanding of the link between adipokines and angiogenesis will open the way for novel therapeutic approaches to treat obesity and metabolic diseases.

Automated summary

Adipose tissue is an active endocrine organ, which secretes adipokines that have various functions in the body. The plasticity of adipose tissue is associated with angiogenesis, which supports tissue expansion. Abnormal production or loss of certain adipokines can lead to metabolic dysfunction related to obesity. Understanding the role of adipokines in angiogenesis may offer new therapeutic approaches for treating obesity and metabolic diseases.