Quantitative imaging approaches to understanding biological processing of metal ions

Faster, more sensitive, and higher resolution quantitative instrumentation are aiding a deeper understanding of how inorganic chemistry regulates key biological processes. Researchers can now image and quantify metals with subcellular resolution, leading to a vast array of new discoveries in organismal development, pathology, and disease. Metals have recently been implicated in several diseases such as Parkinson's, Alzheimers, ischemic stroke, and colorectal cancer that would not be possible without these advancements. In this review, instead of focusing on instrumentation we focus on recent applications of label-free elemental imaging and quantification and how these tools can lead to a broader understanding of metals role in systems biology and human pathology.

Automated summary

Advanced quantitative instrumentation allows for a better understanding of how inorganic chemistry regulates key biological processes, particularly the role of metals in organismal development, pathology, and disease. Recent applications of label-free elemental imaging and quantification have led to the discovery of metal associations with various diseases such as Parkinson's, Alzheimer's, ischemic stroke, and colorectal cancer.