4.5 Article

Development of a multiciliated cell

Journal

CURRENT OPINION IN CELL BIOLOGY
Volume 77, Issue -, Pages -

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2022.102105

Keywords

-

Categories

Funding

  1. Children's Discovery Institute of Washington University
  2. St. Louis Children's Hospital [CDI-CORE2015-505, CDI-CORE-2019-813]
  3. Foundation for BarnesJewish Hospital [3770, 4642]
  4. National Heart, Lung and Blood Institute [R01HL128370]
  5. National Institute of Diabetes and Digestive and Kidney Diseases [R01-DK108005]
  6. Department of Defense e Congressionally Directed Medical Research Programs [W81XWH-20-1-0198]

Ask authors/readers for more resources

This review discusses recent progress in understanding the mechanisms of centriole and cilia biogenesis in multiciliated cells (MCC), and explores how MCC progenitor cells regulate the number of centrioles and cilia during their differentiation.
Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available