Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 76, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2022.102740
Keywords
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Funding
- National University of Singapore Medicine Synthetic Biology Translational Research Programme [NUHSRO/2020/077/MSC/02/SB]
- Summit Research Programme of the National University Health System [NUHSRO/2016/053/SRP/05]
- Synthetic Biology Initiative of the National University of Singapore [DPRT/943/09/14]
- Synthetic Biology R&D Programme of the National Research Foundation of Singapore
- Industry Alignment Fund-Industry Collaboration Project of the Agency for Science, Technology and Research (A*STAR) of Singapore [ICP1600012]
- United States Army [ARO/2019/74459LS]
- Ministry of Eductation of Singapore [MOE/2014/T2/2/128NUHSRO/2020/046/T1/3]
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The review discusses the use of synthetic biology, genomic engineering, and biofoundry tools for the production and genetic modification of SCPs. It also explores the current and potential applications of genetic modification in SCP production for animal feed and human food, as well as the challenges related to technology and policy control.
Single-cell proteins (SCPs) have been widely used in human food and animal feed applications, still, there are challenges in their production and commercialization. Recently, advances in microbial synthetic biology, genomic engineering, and biofoundry technologies have offered capabilities to effectively and rapidly engineer microorganisms for improving the productivity, nutritional, and functional quality of SCPs. In this review, we discuss various synthetic biology, genomic engineering, and biofoundry tools that can be harnessed for SCP production and genetic modification. We also describe the current and potential applications of genetic modification in producing intermediate feedstocks, as well as biomass-based and multifunctional SCPs. Finally, we discuss the technological and policy-control related challenges encountered when deploying genetic modification in SCP production for animal feed and human food applications.
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