4.6 Review

FGF23 Actions in CKD-MBD and other Organs During CKD

Related references

Note: Only part of the references are listed.
Article Cell Biology

Identification of a second Klotho interaction site in the C terminus of FGF23

Archita Agrawal et al.

Summary: FGF23 interacts with a FGFR/KL-receptor complex and has two independent KL-interaction sites at its C terminus, the loss of either leading to protein inactivation. The identification of the second KL-association site provides a potential for enhanced biological effects.

CELL REPORTS (2021)

Review Endocrinology & Metabolism

Upstream Regulators of Fibroblast Growth Factor 23

Danielle M. A. Ratsma et al.

Summary: FGF23 is a key regulator of mineral homeostasis and plays a role in iron deficiency, inflammation, and erythropoiesis. It is essential for maintaining phosphate balance, but its regulation through transcriptional and post-translational mechanisms is complex.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Urology & Nephrology

Secondary hyperparathyroidism and adverse health outcomes in adults with chronic kidney disease

Yang Xu et al.

Summary: The study found that the incidence of SHPT increases with the progression of CKD, with low eGFR being the strongest predictor of SHPT. Developing SHPT was significantly associated with increased risks of death, cardiovascular events, CKD progression, and fractures.

CLINICAL KIDNEY JOURNAL (2021)

Review Endocrinology & Metabolism

Recent Advances in the Role of Diet in Bone and Mineral Disorders in Chronic Kidney Disease

Orlando M. Gutierrez

Summary: High phosphorus consumption worsens CKD-MBD, but dietary counseling can mitigate these effects, for example, by consuming diets with higher calcium to phosphorus ratios.

CURRENT OSTEOPOROSIS REPORTS (2021)

Review Endocrinology & Metabolism

X-Linked Hypophosphatemic Rickets: Multisystemic Disorder in Children Requiring Multidisciplinary Management

Giampiero Igli Baroncelli et al.

Summary: X-linked hypophosphatemic rickets (XLH) is the most common inherited form of rickets caused by impaired regulation of FGF23 due to PHEX gene mutation. Patients with XLH present with rickets, osteomalacia, deformities, and growth impairment, requiring multidisciplinary management for optimal treatment.

FRONTIERS IN ENDOCRINOLOGY (2021)

Review Nutrition & Dietetics

Lessons Learned from Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets Patients on Vitamin D Functions

Dov Tiosano et al.

Summary: Lessons learned from HVDRR patients with dysfunctional VDR include the impact on bone health during childhood, recovery after puberty, unique responses in immune function, and protection against asthma despite vitamin D deficiency. The role of VDR in various human systems, such as the renin angiotensin system and reproductive health, remains important for further study using HVDRR patients as a unique model.

JOURNAL OF NUTRITION (2021)

Review Urology & Nephrology

FGF23 at the crossroads of phosphate, iron economy and erythropoiesis

Daniel Edmonston et al.

NATURE REVIEWS NEPHROLOGY (2020)

Review Physiology

Regulation and Effects of FGF23 in Chronic Kidney Disease

John Musgrove et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 82 (2020)

Article Physiology

The Osteocyte: New Insights

Alexander G. Robling et al.

Annual Review of Physiology (2020)

Review Medicine, General & Internal

Endothelial Dysfunction in Chronic Kidney Disease, from Biology to Clinical Outcomes: A 2020 Update

Stefanos Roumeliotis et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Review Cell Biology

Useful applications of growth factors for cardiovascular regenerative medicine

Maria Rosaria De Pascale et al.

GROWTH FACTORS (2020)

Article Biochemistry & Molecular Biology

Alterations of bone material properties in adult patients with X-linked hypophosphatemia (XLH)

Nadja Fratzl-Zelman et al.

JOURNAL OF STRUCTURAL BIOLOGY (2020)

Review Rheumatology

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Ego Seeman et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Article Multidisciplinary Sciences

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

Ekaterina S. Kuzina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Biochemistry & Molecular Biology

αKlotho-FGF23 interactions and their role in kidney disease: a molecular insight

Edward R. Smith et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Urology & Nephrology

Evolving concepts in the pathogenesis of uraemic cardiomyopathy

Xiaoliang Wang et al.

NATURE REVIEWS NEPHROLOGY (2019)

Review Urology & Nephrology

Renal and extrarenal effects of fibroblast growth factor 23

Marc Vervloet

NATURE REVIEWS NEPHROLOGY (2019)

Article Cardiac & Cardiovascular Systems

Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice

Jeffrey J. Hsu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Endocrinology & Metabolism

X-Linked Hypophosphatemia and FGF23-Related Hypophosphatemic Diseases: Prospect for New Treatment

Yuka Kinoshita et al.

ENDOCRINE REVIEWS (2018)

Article Respiratory System

Fibroblast growth factor 23 and Klotho contribute to airway inflammation

Stefanie Krick et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Article Urology & Nephrology

Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis

Amarnath Marthi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

Review Endocrinology & Metabolism

FGF23 Actions on Target Tissues-with and without Klotho

Beatrice Richter et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

Gaozhi Chen et al.

NATURE (2018)

Review Endocrinology & Metabolism

Role of phosphate sensing in bone and mineral metabolism

Sampada Chande et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Urology & Nephrology

Global Cardiovascular and Renal Outcomes of Reduced GFR

Bemadette Thomas et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Transplantation

Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats

Maren Leifheit-Nestler et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2017)

Article Medicine, General & Internal

Tumour-induced osteomalacia

Salvatore Minisola et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Multidisciplinary Sciences

FGF23/FGFR4-mediated left ventricular hypertrophy is reversible

Alexander Grabner et al.

SCIENTIFIC REPORTS (2017)

Review Endocrinology & Metabolism

Tissue expression and source of circulating αtKlotho

Hannes Olauson et al.

Article Endocrinology & Metabolism

FGF23 Regulates Bone Mineralization in a 1,25(OH) D-2(3) and Klotho-Independent Manner

Sathish Kumar Murali et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

Article Urology & Nephrology

Diagnostic Accuracy of Bone Turnover Markers and Bone Histology in Patients With CKD Treated by Dialysis

Stuart M. Sprague et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2016)

Review Biochemistry & Molecular Biology

Role of inorganic polyphosphate in mammalian cells: from signal transduction and mitochondrial metabolism to cell death

Plamena R. Angelova et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2016)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 23 signaling in hippocampal cells: impact on neuronal morphology and synaptic density

Niko Hensel et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Urology & Nephrology

Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production

Valentin David et al.

KIDNEY INTERNATIONAL (2016)

Meeting Abstract Orthopedics

MAINTENANCE OF CHONDROCYTE SURVIVAL BY PIT1/SLC20A1-MEDIATED REGULATION OF ENDOPLASMIC RETICULUM HOMEOSTASIS

G. Couasnay et al.

OSTEOARTHRITIS AND CARTILAGE (2016)

Article Physiology

Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells

Beatrice Richter et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2016)

Article Endocrinology & Metabolism

Biphasic Effects of Vitamin D and FGF23 on Human Osteoclast Biology

Lise Allard et al.

CALCIFIED TISSUE INTERNATIONAL (2015)

Article Endocrinology & Metabolism

FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes

Ichiro Kaneko et al.

JOURNAL OF ENDOCRINOLOGY (2015)

Article Urology & Nephrology

Klotho and Phosphate Are Modulators of Pathologic Uremic Cardiac Remodeling

Ming Chang Hu et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Review Urology & Nephrology

Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease

Myles Wolf et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2014)

Article Urology & Nephrology

Fibroblast Growth Factor-23 and Cardiovascular Events in CKD

Julia J. Scialla et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Multidisciplinary Sciences

Direct, Acute Effects of Klotho and FGF23 on Vascular Smooth Muscle and Endothelium

Isabelle Six et al.

PLOS ONE (2014)

Review Endocrinology & Metabolism

Inventing new medicines: The FGF21 story

Alexei Kharitonenkov et al.

MOLECULAR METABOLISM (2014)

Article Cell Biology

Fibroblast Growth Factor 23 and Klotho Are Present in the Growth Plate

Adalbert Raimann et al.

CONNECTIVE TISSUE RESEARCH (2013)

Article Endocrinology & Metabolism

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

Masashi Honma et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2013)

Review Endocrinology & Metabolism

Renal Safety in Patients Treated With Bisphosphonates for Osteoporosis: A Review

Paul D. Miller et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2013)

Article Endocrinology & Metabolism

Biological Variability of Plasma Intact and C-Terminal FGF23 Measurements

Edward R. Smith et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Medicine, Research & Experimental

FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality

Victoria Shalhoub et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Urology & Nephrology

Fibroblast Growth Factor 23, Cardiovascular Disease Risk Factors, and Phosphorus Intake in the Health Professionals Follow-up Study

Orlando M. Gutierrez et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)

Article Endocrinology & Metabolism

A Clinician's Guide to X-Linked Hypophosphatemia

Thomas O. Carpenter et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

Article Medicine, Research & Experimental

FGF23 induces left ventricular hypertrophy

Christian Faul et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Review Urology & Nephrology

The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

William G. Couser et al.

KIDNEY INTERNATIONAL (2011)

Article Multidisciplinary Sciences

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

Emily G. Farrow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Endocrinology & Metabolism

Sclerostin: A Gem From the Genome Leads to Bone-Building Antibodies

Chris Paszty et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Hematology

Phosphonoformic Acid Prevents Vascular Smooth Muscle Cell Calcification by Inhibiting Calcium-Phosphate Deposition

Ricardo Villa-Bellosta et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Identification of a Novel Function of PiT1 Critical for Cell Proliferation and Independent of Its Phosphate Transport Activity

Laurent Beck et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Neuropeptide Y Is Expressed by Osteocytes and Can Inhibit Osteoblastic Activity

John C. Igwe et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Article Urology & Nephrology

Dietary Phosphorus Acutely Impairs Endothelial Function

Emi Shuto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Urology & Nephrology

Initial FGF23-Mediated Signaling Occurs in the Distal Convoluted Tubule

Emily G. Farrow et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Review Cell Biology

The Klotho gene family as a regulator of endocrine fibroblast growth factors

Hiroshi Kurosu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Transplantation

Vascular calcifications, vertebral fractures and mortality in haemodialysis patients

Minerva Rodriguez-Garcia et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2009)

Article Urology & Nephrology

Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD

Tamara Isakova et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)

Article Medicine, Research & Experimental

The parathyroid is a target organ for FGF23 in rats

Iddo Z. Ben-Dov et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Transplantation

Regulation of fibroblast growth factor-23 in chronic kidney disease

Per-Anton Westerberg et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2007)

Review Biochemistry & Molecular Biology

Regulation of MAPKs by growth factors and receptor tyrosine kinases

Menachem Katz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Cellular signaling by fibroblast growth factor receptors

VP Eswarakumar et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2005)

Article Biochemistry & Molecular Biology

Circulating FGF-23 is regulated by 1α,25-dihydroxyvitamin D3 and phosphorus in vivo

H Saito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Endocrinology & Metabolism

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

T Shimada et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2004)

Review Dentistry, Oral Surgery & Medicine

The wrickkened pathways of FGF23, MEPE and PHEX

PSN Rowe

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE (2004)

Article Multidisciplinary Sciences

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

L Hessle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Urology & Nephrology

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

KE White et al.

KIDNEY INTERNATIONAL (2001)

Article Cell Biology

Phosphate-induced chondrocyte apoptosis is linked to nitric oxide generation

CC Teixeira et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2001)

Article Cardiac & Cardiovascular Systems

Phosphate regulation of vascular smooth muscle cell calcification

S Jono et al.

CIRCULATION RESEARCH (2000)