Journal
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2022.2098671
Keywords
Aptamer; aptasensor; DNAzymes; nanosensor; thrombin
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Funding
- Mashhad University of Medical Sciences (MUMS), Mashhad, Iran
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Thrombin, a key protein involved in hemostasis and tissue adhesion, is important in clinical detection. Aptasensors and nanoaptasensors based on DNAzymes have shown promise in accurate thrombin detection. This article reviews the progress made in DNAzyme-based aptasensors and nanoaptasensors for thrombin detection, and discusses the challenges and prospects in this field.
Thrombin (TB) is classified among human blood coagulation proteins with key functions in hemostasis of blood vessels, wound healing, atherosclerosis, tissue adhesion, etc. Moreover, TB is involved as the main enzyme in the conversion of the fibrinogen to fibrin. Given the importance of TB detection in the clinical area, the development of innovative methods can considerably improve TB detection. Newly, aptasensors or aptamer-based biosensors have received special attention for sensitive and facile TB detection. In addition, the aptamer/nanomaterial conjugates have presented new prospects in accurate TB detection as nanoaptasensors. DNA-based enzymes or DNAzymes, as new biocatalysts, have many advantages over protein enzymes and can be used in analytical tools. This article reviews a brief overview of significant progresses regarding the various types of DNAzymes-based aptasensors and nano aptasensors developed for thrombin detection. In the following, challenges and prospects of TB detection by DNAzymes-based aptasensors are discussed.
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