Related references
Note: Only part of the references are listed.Properties of FDA-approved small molecule protein kinase inhibitors: A 2021 update
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2021)
ATP-Magnesium Coordination: Protein Structure-Based Force Field Evaluation and Corrections
Floris P. Buelens et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2021)
Kinase drug discovery 20 years after imatinib: progress and future directions
Philip Cohen et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
Trends in kinase drug discovery: targets, indications and inhibitor design (Aug, 10.1038/s41573-021-00252-y, 2021)
Misty M. Attwood et al.
NATURE REVIEWS DRUG DISCOVERY (2021)
KinaseMD: kinase mutations and drug response database
Ruifeng Hu et al.
NUCLEIC ACIDS RESEARCH (2021)
Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials
Stephen A. Harrison et al.
JOURNAL OF HEPATOLOGY (2020)
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors
Zhili Xin et al.
ACS MEDICINAL CHEMISTRY LETTERS (2020)
Small molecules, big impact: 20 years of targeted therapy in oncology
Philippe L Bedard et al.
LANCET (2020)
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1)
Shiyan Zhang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Molecular insight into the T798M gatekeeper mutation-caused acquired resistance to tyrosine kinase inhibitors in ErbB2-positive breast cancer
Ji Lu et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY (2019)
Defining a new nomenclature for the structures of active and inactive kinases
Vivek Modi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis
Tenagne D. Challa et al.
EMBO MOLECULAR MEDICINE (2019)
ASK1 and its role in cardiovascular and other disorders: available treatments and future prospects
Mohammad Hassan Baig et al.
EXPERT REVIEW OF PROTEOMICS (2019)
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors
Martin K. Himmelbauer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders
So Yeong Cheon et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2019)
Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors
Andrii Monastyrskyi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Kinase inhibitors: the road ahead
Fleur M. Ferguson et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Exploring the Stability of Ligand Binding Modes to Proteins by Molecular Dynamics Simulations: A Cross-docking Study
Kai Liu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
The target landscape of clinical kinase drugs
Susan Klaeger et al.
SCIENCE (2017)
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure
Marion Lanier et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Yulia Haim et al.
MOLECULAR METABOLISM (2017)
Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy
Tony S. Gibson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
Yong Jia et al.
NATURE (2016)
Kinase Drug Discovery - What's Next in the Field?
Philip Cohen et al.
ACS CHEMICAL BIOLOGY (2013)
Sequence Determinants of a Specific Inactive Protein Kinase Conformation
Sanjay B. Hari et al.
CHEMISTRY & BIOLOGY (2013)
Confirming the Importance of the R-Spine: New Insights into Protein Kinase Regulation
Richard Robinson
PLOS BIOLOGY (2013)
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors
Yoshito Terao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Evaluation of WO2012003387, Gilead's ASK1 inhibitors
Peter Norman
EXPERT OPINION ON THERAPEUTIC PATENTS (2012)
Identification of novel ASK1 inhibitors using virtual screening
Masako Okamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Marie Cargnello et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)
Pathological roles of MAPK signaling pathways in human diseases
Eun Kyung Kim et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
EGFR T790M Mutation: A Double Role in Lung Cancer Cell Survival?
Kenichi Suda et al.
Journal of Thoracic Oncology (2010)
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Cai-Hong Yun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Structural and functional characterization of the human protein kinase ASK1
Gabor Bunkoczi et al.
STRUCTURE (2007)
Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
S Blencke et al.
CHEMISTRY & BIOLOGY (2004)
Share Paper
