Journal
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
Volume 21, Issue 5, Pages 3804-3833Publisher
WILEY
DOI: 10.1111/1541-4337.13007
Keywords
gastric emptying; gastrointestinal motility; gastrointestinal tract; in vitro model; in vitro-in vivo correlation; simulation
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Funding
- USDA National Institute of Food Agriculture [2019-67021-29859, 1019017]
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This review summarizes the characteristics of gastric and small intestinal motility in humans, as well as the biomechanical and hydrodynamic events related to gut motility. The performance of various dynamic in vitro models in simulating gastrointestinal motility is evaluated.
The application of dynamic in vitro gastrointestinal (GI) models has grown in popularity to understand the impact of food structure and composition on human health. Given that GI motility is integral to digestion and absorption, a predictive in vitro model should faithfully replicate the motility patterns and motor functions in vivo. In this review, typical characteristics of gastric and small intestinal motility in humans as well as the biomechanical and hydrodynamic events pertinent to gut motility are summarized. The simulation of GI motility in the presently existing dynamic in vitro models is discussed from an engineering perspective and categorized into hydraulic, piston/probe-driven, roller-driven, pneumatic, and other systems. Each system and its representative models are evaluated in terms of their motility patterns, the key hydrodynamic characteristics concerning gut motility, their performance in simulating the key physiological events, and their ability to establish in vitro-in vivo correlations.
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