Journal
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
Volume 21, Issue 4, Pages 3326-3345Publisher
WILEY
DOI: 10.1111/1541-4337.12974
Keywords
Endoplasmic reticulum stress; Oxidative stress; Toxicity; Zearalenone
Categories
Funding
- National Natural Science Foundation of China [31625025]
Ask authors/readers for more resources
This review summarizes the characteristics, metabolism, toxicity, and deleterious effects of Zearalenone (ZEA) exposure in various tissues of animals. The article highlights the involvement of stress response signaling in ZEA toxicity and discusses potential therapeutic options for reducing the harmful effects of ZEA in animals.
Zearalenone (ZEA) is a mycotoxin frequently found in cereal crops and cereal-derived foodstuffs worldwide. It affects plant productivity, and is also a serious hazard to humans and animals if being exposed to food/feed contaminated by ZEA. Studies over the last decade have shown that the toxicity of ZEA in animals is mainly mediated by the various stress responses, such as endoplasmic reticulum (ER) stress, oxidative stress, and others. Accumulating evidence shows that oxidative stress and ER stress signaling are actively implicated in and contributes to the pathophysiology of various diseases. Biochemically, the deleterious effects of ZEA are associated with apoptosis, DNA damage, and lipid peroxidation by regulating the expression of genes implicated in these biological processes. Despite these findings, the underlying mechanisms responsible for these alterations remain unclear. This review summarized the characteristics, metabolism, toxicity and the deleterious effects of ZEA exposure in various tissues of animals. Stress response signaling implicated in the toxicity as well as potential therapeutic options with the ability to reduce the deleterious effects of ZEA in animals were highlighted and discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available