Journal
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Volume 257, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2022.109334
Keywords
Honeybees; Apis mellifera intermissa; Thiamethoxam; Oxidative stress; Lipid peroxidation; Neurotoxicity
Funding
- National Fund for Scientific Research of Algeria (Laboratory of Applied Animal Biology)
- Ministry of Higher Education and Scientific Research of Algeria (PRFU project)
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In this study, honeybees were orally exposed to a sublethal concentration of thiamethoxam under laboratory conditions, and the effects on honeybee physiology were evaluated by monitoring specific biomarkers. Results showed that thiamethoxam induced oxidative stress and defense mechanisms in honeybees.
Thiamethoxam is an insecticide mainly used in agriculture to control insect pests. However, non-target insect species, such as honeybees, may also be impacted. In this study, adults of Apis mellifera intermissa were orally exposed under laboratory conditions to a sublethal concentration of thiamethoxam (CL25 = 0.17 ng/mu l) for 9 days and the effects were evaluated at the biochemical level, by monitoring specific oxidative stress and neuronal biomarkers. Results showed an increase in the antioxidant enzymes, glutatione-S-transferase (GST), catalase (CAT) and glutathione peroxidase (GPx) and in content of malondialdehyde (MDA). The activity of acetylcholinesterase (AChE) was downregulated as evidence of a neurotoxic action and no significant change was observed in glutathione (GSH). Exposure to the insecticide thiamethoxam induced oxidative stress and defense mechanisms affecting honeybee physiology.
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