4.6 Article

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Lipid-Lowering and Antioxidant Activity of RF13 Peptide From Vacuolar Protein Sorting-Associated Protein 26B (VPS26B) by Modulating Lipid Metabolism and Oxidative Stress in HFD Induced Obesity in Zebrafish Larvae

Ajay Guru et al.

Summary: This study investigates the lipid-lowering and antioxidant effects of RF13 peptide derived from VPS26B in zebrafish larvae fed with a high fat diet (HFD). The results show that RF13 significantly reduces cholesterol and triglycerides levels, enhances antioxidant enzyme levels, and decreases lipid peroxidation and accumulation in zebrafish larvae. RF13 also regulates lipid metabolism and upregulates antioxidant-related genes.

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2022)

Article Fisheries

Intracellular ROS scavenging and antioxidant regulation of WL15 from cysteine and glycine-rich protein 2 demonstrated in zebrafish in vivo model

Ajay Guru et al.

Summary: The study showed that WL15 peptide possesses strong antioxidant properties, which were validated through in vitro and in vivo experiments. Results from zebrafish experiments demonstrated that WL15 peptide can reduce intracellular ROS levels and inhibit apoptotic responses induced by H2O2.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Tryptophan-tagged peptide from serine threonine-protein kinase of Channa striatus improves antioxidant defence in L6 myotubes and attenuates caspase 3-dependent apoptotic response in zebrafish larvae

Praveen Kumar Issac et al.

Summary: The tryptophan-tagged peptide IW13 derived from Channa striatus fish showed strong antioxidant properties without cytotoxicity to L6 cells, and upregulated antioxidant enzyme genes, demonstrating its potential as a promising candidate for treating oxidative stress-related diseases.

FISH PHYSIOLOGY AND BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS

Dalia M. Ezzat et al.

Summary: Nicorandil protects against folic acid-induced acute kidney injury by alleviating oxidative stress, inflammation, modulating nitric oxide synthase, and reducing apoptosis in a dose-dependent manner.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Review Biochemistry & Molecular Biology

Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds

Ajay Guru et al.

Summary: Obesity is on the rise, leading to various health complications. Herbal medicines are considered an ancient method for treating obesity-related issues. Understanding the development of adipose tissue and the molecular mechanisms involved is crucial in therapeutic approaches for obesity.

MOLECULAR BIOLOGY REPORTS (2021)

Article Biotechnology & Applied Microbiology

GR15 peptide of S-adenosylmethionine synthase (SAMe) from Arthrospira platensis demonstrated antioxidant mechanism against H2O2 induced oxidative stress in in-vitro MDCK cells and in-vivo zebrafish larvae model

Manikandan Velayutham et al.

Summary: GR15, a short peptide composed of aliphatic amino acids, possesses antioxidant properties with dose-dependent activity demonstrated through cell-free antioxidant assays, showing protective effects against oxidative stress. It exhibits non-toxicity in both in vitro and in vivo models, effectively reducing ROS levels.

JOURNAL OF BIOTECHNOLOGY (2021)

Article Medicine, Research & Experimental

Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing therapeutic implications

Praveen Kumar Issac et al.

Summary: The study demonstrated that morin provides neuroprotection in zebrafish larvae by restoring antioxidant enzyme activity and reducing lipid peroxidation to alleviate oxidative stress-induced cellular apoptosis and ROS levels. This mechanism enhances cellular antioxidant defense and could be a novel strategy for combating oxidative stress.

LIFE SCIENCES (2021)

Article Cell Biology

Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine-rich protein 2 in high glucose-induced rat skeletal muscle L6 cells

Ajay Guru et al.

Summary: The study found that the WL15 peptide derived from Channa striatus exhibits good antioxidant and antidiabetic activities in rat skeletal muscle cells without cytotoxic effects. By increasing antioxidant enzymes, WL15 peptide reduces oxidative stress and lipid peroxidation, while also increasing glucose uptake and glycogen storage for its antidiabetic effects.

CELL BIOLOGY INTERNATIONAL (2021)

Article Multidisciplinary Sciences

GP13, an Arthrospira platensis cysteine desulfurase-derived peptide, suppresses oxidative stress and reduces apoptosis in human leucocytes and zebrafish (Danio rerio) embryo via attenuated caspase-3 expression

Purabi Sarkar et al.

Summary: The study identified a novel peptide, GP13, derived from ApCDS, with significant antioxidant activity both in vitro and in vivo, protecting cells from oxidative stress damage.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2021)

Article Cell Biology

NV14 from serine O-acetyltransferase of cyanobacteria influences the antioxidant enzymes in vitro cells, gene expression against H2O2 and other responses in vivo zebrafish larval model

Manikandan Velayutham et al.

Summary: The study identified a novel peptide, NV14, with potent antioxidant properties derived from serine O-acetyltransferase (SAT) of Artrospira platensis. NV14 showed non-cytotoxicity in vitro, enhanced antioxidant enzyme activity, and upregulated gene expression in zebrafish larvae under oxidative stress. Overall, NV14 demonstrated antioxidant effects in both in vitro and in vivo assays.

CELL BIOLOGY INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Insulin signaling pathway assessment by enhancing antioxidant activity due to morin using in vitro rat skeletal muscle L6 myotubes cells

Praveen Kumar Issac et al.

Summary: Morin acts as an antioxidant by reducing ROS levels and demonstrating insulin mimetic activity, reversing insulin resistance associated with oxidative stress.

MOLECULAR BIOLOGY REPORTS (2021)

Article Cell Biology

Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages

Hassan Laaroussi et al.

Summary: The study found that honey and propolis have protective effects in preventing and improving oxidative stress and liver and kidney dysfunction induced by gentamicin. Propolis extract has high antioxidant power due to the presence of various beneficial phenolic compounds, while honey mainly contains hydroxybenzoic acids and hydroxycinnamic acids.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Biotechnology & Applied Microbiology

Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions

Yingcai Hong et al.

Summary: The study revealed that the expressions of HSP27, HSP70, and SGP130 increased in HF rats complicated with pulmonary edema, significantly affecting the cardiopulmonary functions of the rats.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Nephroprotective effects of eriocitrin via alleviation of oxidative stress and DNA damage against cisplatin-induced renal toxicity

Yongsheng Jing et al.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI (2020)

Article Biochemistry & Molecular Biology

Molecular process of glucose uptake and glycogen storage due to hamamelitannin via insulin signalling cascade in glucose metabolism

Praveen Kumar Issac et al.

MOLECULAR BIOLOGY REPORTS (2020)

Article Environmental Sciences

Sulphated polysaccharide from Sargassum myriocystum confers protection against gentamicin-induced nephrotoxicity in adult zebrafish

Durairaj Vaishnu Devi et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

Article Fisheries

Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish

Seon-Heui Cha et al.

FISH & SHELLFISH IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Environmental Sciences

Exposure to difenoconazole causes changes of thyroid hormone and gene expression levels in zebrafish larvae

Xiao Liang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

Article Cell & Tissue Engineering

Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration

Kristen K. McCampbell et al.

STEM CELLS INTERNATIONAL (2015)

Review Urology & Nephrology

New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view

Jose M. Lopez-Novoa et al.

KIDNEY INTERNATIONAL (2011)

Review Neurosciences

Role of interleukin-1β during pain and inflammation

Ke Ren et al.

BRAIN RESEARCH REVIEWS (2009)