Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 216, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.112530
Keywords
Pectin; Langmuir monolayers; Antiviral; Bactericide; cellular membranes
Funding
- Funda?a?o de Amparo a` Pesquisa do Estado de Sa?o Paulo, FAPESP, Brazil [19/03239-0, 18/22214-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [19/03239-0] Funding Source: FAPESP
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This study investigated the effects of inserting pectin into lipid monolayers. Pectin made the DPPC monolayer more fluid, while it made the DPPE monolayer more rigid.
Pectin, a polysaccharide with potential bioactivity, was inserted in the aqueous subphase of monolayers of selected lipids DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and DPPE (1,2-dipalmitoyl-sn-glycero-3phosphoethanolamine), representing mammalian and bacterial membranes, respectively. Pectin condensed monolayers but made the DPPC monolayer more fluid, while for DPPE, it made its monolayer more rigid, detected with dynamic interfacial rheology. Complementary data using surface potential, infrared spectroscopy, and Brewster angle microscopy also showed distinctive effects of pectin on DPPE and DPPC. We believe these data can be correlated with the action of this polysaccharide with biological lipidic surfaces with different polar heads, which may be relevant, generally speaking, to understanding the molecular mechanism of this bioactive compound for pharmaceutical purposes.
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