Journal
CNS NEUROSCIENCE & THERAPEUTICS
Volume 28, Issue 9, Pages 1294-1302Publisher
WILEY
DOI: 10.1111/cns.13893
Keywords
drug target; epilepsy; excitability; Na plus -K plus -ATPase
Categories
Funding
- National Natural Science Foundation of China [81973298]
- Natural Science Foundation of Zhejiang Province [LD22H310003]
Ask authors/readers for more resources
This review comprehensively summarizes the role of Na+-K+-ATPase in epilepsy and provides perspectives on possible research directions and therapeutic targets.
Na+-K+-ATPase, a P-type ATP-powered ion transporter on cell membrane, plays a vital role in cellular excitability. Cellular hyperexcitability, accompanied by hypersynchronous firing, is an important basis for seizures/epilepsy. An increasing number of studies point to a significant contribution of Na+-K+-ATPase to epilepsy, although discordant results exist. In this review, we comprehensively summarize the structure and physiological function of Na+-K+-ATPase in the central nervous system and critically evaluate the role of Na+-K+-ATPase in the epileptic brain. Importantly, we further provide perspectives on some possible research directions and discuss its potential as a therapeutic target for the treatment of epilepsy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
