4.5 Review

Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

In situ-gelling starch nanoparticle (SNP)/O-carboxymethyl chitosan (CMCh) nanoparticle network hydrogels for the intranasal delivery of an antipsychotic peptide

Michael J. Majcher et al.

Summary: Intranasal delivery of peptide drug PAOPA via novel nanoparticle hydrogels shows prolonged therapeutic effects in a rat model of schizophrenia, offering potential for reduced drug doses and administration frequencies.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Neurosciences

Increased functional coupling of the mu opioid receptor in the anterior insula of depressed individuals

Pierre-Eric Lutz et al.

Summary: Research indicates that depression is associated with increased MOR activity, partially explained by a specific increase in expression of the inhibitory alpha G-protein subunit GNAI2. This enhanced endogenous opioidergic tone may help buffer negative affective states in depressed individuals.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Differential effect of anesthetics on mucociliary clearance in vivo in mice

Kyle S. Feldman et al.

Summary: Respiratory mucociliary clearance is a crucial defense mechanism that helps remove inhaled pollutants and pathogens from the lungs. Anesthetics containing ketamine were found to significantly depress this mechanism, while combinations containing fentanyl and propofol did not have a significant impact.

SCIENTIFIC REPORTS (2021)

Review Pharmacology & Pharmacy

Nanotechnologies for intranasal drug delivery: an update of literature

Rosamaria Lombardo et al.

Summary: Recent scientific research has focused on finding alternative routes for drug administration, particularly through intranasal delivery coupled with DDS for improved drug delivery outcomes.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Review Pharmacology & Pharmacy

Gene therapy for neurological disorders: challenges and recent advancements

Stefanie A. Pena et al.

JOURNAL OF DRUG TARGETING (2020)

Article Biotechnology & Applied Microbiology

Advances in oral peptide therapeutics

Daniel J. Drucker

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Pharmacology & Pharmacy

Nanoparticlized System: Promising Approach for the Management of Alzheimer's Disease through Intranasal Delivery

Shiv Bahadur et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Review Pharmacology & Pharmacy

Nose-to-brain delivery of antipsychotics using nanotechnology: a review

Madeleine S. A. Tan et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

Editorial Material Medicine, General & Internal

Mental Health and the Covid-19 Pandemic

Betty Pfefferbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Neurosciences

Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer's Disease: A Recent Update

Manisha Pandey et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2020)

Article Multidisciplinary Sciences

A Positioning Device for the Placement of Mice During Intranasal siRNA Delivery to the Central Nervous System

Irfan Ullah et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

Review Pharmacology & Pharmacy

Drug Delivery and Targeting to the Brain Through Nasal Route: Mechanisms, Applications and Challenges

Kanchan Kashyap et al.

CURRENT DRUG DELIVERY (2019)

Article Allergy

Inadequate quality of administration of intranasal corticosteroid sprays

Corine Rollema et al.

JOURNAL OF ASTHMA AND ALLERGY (2019)

Review Neurosciences

Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions

Jung Hyun Lee et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Biochemistry & Molecular Biology

Diazepam-induced loss of inhibitory synapses mediated by PLCδ/Ca2+/calcineurin signalling downstream of GABAA receptors

Martin W. Nicholson et al.

MOLECULAR PSYCHIATRY (2018)

Article Pharmacology & Pharmacy

In situ gelling and mucoadhesive polymers: why do they need each other?

Forouhe Zahir-Jouzdani et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

Article Respiratory System

Sex differences in respiratory function

Antonella LoMauro et al.

BREATHE (2018)

Article Neurosciences

Phase IIb Study of Intranasal Glutathione in Parkinson's Disease

Laurie K. Mischley et al.

JOURNAL OF PARKINSONS DISEASE (2017)

Article Nanoscience & Nanotechnology

The nasal delivery of nanoencapsulated statins - an approach for brain delivery

Adryana Clementino et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2016)

Article Chemistry, Medicinal

Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

Keon-Hyoung Song et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2015)

Article Multidisciplinary Sciences

Intranasal Administration of CNS Therapeutics to Awake Mice

Leah R. Hanson et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2013)

Review Pharmacology & Pharmacy

Intranasal delivery of biologics to the central nervous system

Jeffrey J. Lochhead et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Review Pharmacology & Pharmacy

Intranasal delivery of therapeutic proteins for neurological diseases

Francesca Malerba et al.

EXPERT OPINION ON DRUG DELIVERY (2011)

Review Pharmacology & Pharmacy

Nasal route: an alternative approach for antiemetic drug delivery

Yildiz Ozsoy et al.

EXPERT OPINION ON DRUG DELIVERY (2011)

Review Pharmacology & Pharmacy

Mucoadhesive drug delivery systems

Rahamatullah Shaikh et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2011)

News Item Medicine, General & Internal

Zicam Update

[Anonymous]

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)

Article Endocrinology & Metabolism

Metoclopramide in the treatment of diabetic gastroparesis

Allen Lee et al.

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM (2010)

Review Pharmacology & Pharmacy

Drug metabolism and pharmacokinetics

Margherita Strolin Benedetti et al.

DRUG METABOLISM REVIEWS (2009)

Article Pharmacology & Pharmacy

Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium

Alpesh Mistry et al.

JOURNAL OF DRUG TARGETING (2009)

Review Pharmacology & Pharmacy

Intranasal Drug Delivery: How, Why and What for?

Anaisa Pires et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2009)

Article Psychology, Biological

Olfactory perception, communication, and the nose-to-brain pathway

U Stockhorst et al.

PHYSIOLOGY & BEHAVIOR (2004)

Article Pharmacology & Pharmacy

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats

C Dufes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2003)

Article Cell Biology

Ensheathment of the olfactory nerves in the adult rat

PM Field et al.

JOURNAL OF NEUROCYTOLOGY (2003)

Article Chemistry, Multidisciplinary

Nasal drug delivery - possibilities, problems and solutions

L Illum

JOURNAL OF CONTROLLED RELEASE (2003)

Review Pharmacology & Pharmacy

Absorption enhancers for nasal drug delivery

SS Davis et al.

CLINICAL PHARMACOKINETICS (2003)

Article Chemistry, Medicinal

Comparison of the flow properties of aqueous suspension corticosteroid nasal sprays under differing sampling conditions

SA Sharpe et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2003)

Review Pharmacology & Pharmacy

Permeability issues in nasal drug delivery

P Arora et al.

DRUG DISCOVERY TODAY (2002)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of intranasal sumatriptan

E Fuseau et al.

CLINICAL PHARMACOKINETICS (2002)

Article Pharmacology & Pharmacy

Transport of nanoparticles across the rat nasal mucosa

J Brooking et al.

JOURNAL OF DRUG TARGETING (2001)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of quetiapine - An atypical antipsychotic

CL DeVane et al.

CLINICAL PHARMACOKINETICS (2001)