4.6 Article

Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology-A Proof-of-Concept Model Development for Remdesivir

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Yingjun Li et al.

Summary: The article reports that the parent nucleoside of remdesivir, GS-441524, shows potent inhibition of SARS-CoV-2 replication and has high efficacy in reducing viral titers in infected organs without notable toxicity in animal studies.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Chemistry, Multidisciplinary

Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice

Wen-juan Hu et al.

Summary: In this study, the pharmacokinetics and tissue distributions of Remdesivir in mice were evaluated, showing different levels and metabolic stabilities of RDV and its metabolites in blood as well as high concentrations in lung, liver, and kidney.

ACTA PHARMACOLOGICA SINICA (2021)

Review Microbiology

Remdesivir against COVID-19 and Other Viral Diseases

Jakob J. Malin et al.

Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.

CLINICAL MICROBIOLOGY REVIEWS (2021)

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Pharmacology & Pharmacy

Challenges of drug development during the COVID-19 pandemic: Key considerations for clinical trial designs

Jun Shi et al.

Summary: This article focuses on translational science principles and strategies for conducting clinical trials in a pandemic in order to expedite the development and approval of COVID-19 therapies.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Medicine, Research & Experimental

COVID-19: Does the infectious inoculum dose-response relationship contribute to understanding heterogeneity in disease severity and transmission dynamics?

Wim Van Damme et al.

Summary: The dose of virus in the initial inoculum may be related to the severity of COVID-19 disease and its transmission potential, leading to severe local outbreaks and large-scale epidemics in certain contexts. Further research is needed to validate this hypothesis.

MEDICAL HYPOTHESES (2021)

Review Cell Biology

COVID-19: Characteristics and Therapeutics

Rameswari Chilamakuri et al.

Summary: The novel coronavirus (COVID-19) has significantly impacted the world since its emergence at the end of 2019, but there have been major advancements in our understanding of the virus and development of treatment options and vaccines to control the pandemic.

CELLS (2021)

Review Pharmacology & Pharmacy

Systematic Review and Patient-Level Meta-Analysis of SARS-CoV-2 Viral Dynamics to Model Response to Antiviral Therapies

Silke Gastine et al.

Summary: A meta-analysis was conducted to study the viral dynamics of SARS-CoV-2 in humans, revealing that older age, male gender, and more severe illness are associated with longer viral clearance times. Remdesivir and interferon combined with ribavirin were found to accelerate viral clearance, suggesting further investigation into combination therapy. The study has established a viral dynamic dataset and NLME model for designing and analyzing antiviral trials.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

Article Immunology

Blood Interferon-α Levels and Severity, Outcomes, and Inflammatory Profiles in Hospitalized COVID-19 Patients

Marco Contoli et al.

Summary: This study demonstrates that COVID-19 patients have lower levels of blood IFN-alpha compared to controls, and as the disease progresses, the IFN-alpha levels decrease while IL-10 expression increases. Survivors show a significant increase in IFN-alpha levels, while patients who died had higher levels of IL-10.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cardiac & Cardiovascular Systems

COVID-19: Why does disease severity vary among individuals?

Saeed Samadizadeh et al.

Summary: The severity of COVID-19 varies significantly among individuals and populations, with differences in reported disease burdens and case fatality rates between countries. The influence of host, virus, and environment on the clinical outcome of the disease is complex and still not fully understood.

RESPIRATORY MEDICINE (2021)

Review Pharmacology & Pharmacy

Remdesivir for the treatment of COVID 19: review of the pharmacological properties, safety and clinical effectiveness

Ashesha Mechineni et al.

Summary: Remdesivir has shown effectiveness in reducing recovery time and improving clinical outcomes in COVID-19 patients, particularly in those with early presentation and moderate disease. Despite not reducing mortality, it is well tolerated and has an acceptable safety profile in both pediatric and adult populations.

EXPERT OPINION ON DRUG SAFETY (2021)

Article Infectious Diseases

Characteristics of COVID-19 infection in Beijing

Sijia Tian et al.

JOURNAL OF INFECTION (2020)

Article Pharmacology & Pharmacy

Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019

Cong Shen et al.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2020)

Article Allergy

Type I IFN immunoprofiling in COVID-19 patients

Sophie Trouillet-Assant et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2

Daniel J. Jackson et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19

Sarah C. J. Jorgensen et al.

PHARMACOTHERAPY (2020)

Article Pharmacology & Pharmacy

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Ka-Tim Choy et al.

ANTIVIRAL RESEARCH (2020)

Article Medicine, Research & Experimental

Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID-19, in Healthy Subjects

Rita Humeniuk et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

Article Infectious Diseases

Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity

Maria Pilar Guallar et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Infectious Diseases

Mild versus severe COVID-19: Laboratory markers

Thirumalaisamy P. Velavan et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

Review Pharmacology & Pharmacy

Challenges for Drug Repurposing in the COVID-19 Pandemic Era

Janet Sultana et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Public, Environmental & Occupational Health

COVID-19: A Risk Assessment Perspective

Imke Schroder

ACS CHEMICAL HEALTH & SAFETY (2020)

Article Pharmacology & Pharmacy

Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load

Antonio Goncalves et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2020)

Article Pediatrics

Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance

[Anonymous]

PEDIATRIA I MEDYCYNA RODZINNA-PAEDIATRICS AND FAMILY MEDICINE (2020)

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Pharmacology & Pharmacy

A Critical Role for Immune System Response in Mediating Anti-influenza Drug Synergies Assessed by Mechanistic Modeling

Z. Li et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2014)

Article Virology

Dynamics of Influenza Virus Infection and Pathology

Roberto A. Saenz et al.

JOURNAL OF VIROLOGY (2010)

Article Medicine, General & Internal

Treatment of SARS with human interferons

J Cinatl et al.

LANCET (2003)