Tiny Gatekeepers: Microbial Control of Host Drug Transporters

Understanding interindividual variations in drug metabolism and disposition is critical to reduce patient morbidity and mortality. The microbiome contributes to such variations in part through the direct metabolism of drugs; however, the ability of host-associated microbial communities to control other aspects of drug disposition, such as absorption, remains poorly understood. Here, we highlight recent studies implicating microbes in the control of host drug influx and efflux transporters and discuss key areas for future studies.

Automated summary

Understanding interindividual variations in drug metabolism and disposition is crucial for reducing patient morbidity and mortality. The microbiome plays a role in these variations by directly metabolizing drugs, but its control over other aspects of drug disposition, such as absorption, is not well understood. This article highlights recent studies on the role of microbiota in controlling host drug transporters and identifies key areas for future research.