Non-actionable Results, Accuracy, and Effect of First- and Second-line Line Probe Assays for Diagnosing Drug-Resistant Tuberculosis, Including on Smear-Negative Specimens, in a High-Volume Laboratory

Article Pathology

Frequent Suboptimal Thermocycler Ramp Rate Usage Negatively Impacts GenoType MTBDRsl VER 2.0 Performance for Second-Line Drug-Resistant Tuberculosis Diagnosis

Brigitta Derendinger et al.

Summary: Strengthening the detection of second-line drug-resistant tuberculosis is crucial. The performance of GenoType MTBDRsl VER 2.0 is affected by the ramp rate used, and using the manufacturer-recommended ramp rate improves its performance. Suboptimal ramp rate contributes to poor performance.

JOURNAL OF MOLECULAR DIAGNOSTICS (2022)

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Article Infectious Diseases

Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study

Adam Penn-Nicholson et al.

Summary: The Xpert MTB/XDR assay demonstrated high diagnostic accuracy in detecting drug-resistant tuberculosis and has the potential to rapidly and accurately diagnose the disease, enabling proper treatment.

LANCET INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Can the GeneXpert MTB/XDR deliver on the promise of expanded, near-patient tuberculosis drug-susceptibility testing?

Kogieleum Naidoo et al.

Summary: Early diagnosis is crucial for tuberculosis elimination by 2035. Current diagnostics for drug-resistant tuberculosis are limited, but the Xpert MTB/XDR assay shows promise for improving access to testing. However, its effectiveness may be affected by changes in treatment methods and definitions of drug resistance.

LANCET INFECTIOUS DISEASES (2022)

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Letter Respiratory System