☆ 4.7 Article

Clinical Characteristics and Outcomes of Immunocompromised Patients With Coronavirus Disease 2019 Caused by the Omicron Variant: A Prospective, Observational Study

CLINICAL INFECTIOUS DISEASES (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Medicinal

Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance

Jiahui Chen et al.

Summary: The Omicron variant of the SARS-CoV-2 virus has caused global panic due to its high infectivity and ability to escape vaccines. A comprehensive analysis using an artificial intelligence model and antibody structure analysis reveals that Omicron may be over 10 times more contagious than the original virus and has an 88% likelihood of vaccine escape. This study highlights the importance of developing mutation-proof vaccines and antibodies.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)

Add to Collection

News Item Medicine, General & Internal

Nature does things well

[Anonymous]

EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE (2022)

Add to Collection

Article Multidisciplinary Sciences

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Yunlong Cao et al.

Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.

NATURE (2022)

Add to Collection

Letter Medicine, General & Internal

Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant

Emi Takashita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Add to Collection

Article Immunology

The RECOVAC Immune-response Study: The Immunogenicity, Tolerability, and Safety of COVID-19 Vaccination in Patients With Chronic Kidney Disease, on Dialysis, or Living With a Kidney Transplant

Jan-Stephan F. Sanders et al.

Summary: In kidney patients, the immunogenicity, tolerability, and safety of COVID-19 vaccination vary. Kidney transplant recipients have a poor immune response, while patients with CKD G4/5 and those on dialysis have a comparable response to the control group. Dialysis patients and transplant recipients experience fewer adverse events after vaccination.

TRANSPLANTATION (2022)

Add to Collection

Review Public, Environmental & Occupational Health

Clinical characteristics and outcome of coronavirus disease 2019 infection in patients with solid organ transplants: A systematic review and meta-analysis

Wen An et al.

Summary: This study conducted a meta-analysis to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid organ transplant recipients. The results showed that while the morbidity rate of COVID-19 in SOT recipients was not significantly higher than the general population, the mortality rate and proportion of severe infection were higher.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2022)

Add to Collection

Article Immunology

Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients

Corine H. GeurtsvanKessel et al.

Summary: This study demonstrates that vaccinated individuals retain T cell immunity to the SARS-CoV-2 Omicron variant, despite low levels of neutralizing antibodies. Booster vaccinations can partially restore cross-neutralization of the Omicron variant.

SCIENCE IMMUNOLOGY (2022)

Add to Collection

Article Surgery

Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic

Madeleine R. Heldman et al.

Summary: Mortality among solid organ transplant recipients hospitalized for COVID-19 decreased between early and late 2020, with the late period showing lower mortality even after adjusting for baseline comorbidities. The use of corticosteroids and remdesivir increased, while the use of hydroxychloroquine and IL-6/IL-6 receptor inhibitors decreased between the two periods.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

Add to Collection

Editorial Material Infectious Diseases

Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022

Jannik Fonager et al.

EUROSURVEILLANCE (2022)

Add to Collection

Article Medicine, General & Internal

Symptom prevalence, duration, and risk of hospital admission in individuals infected with SARS-CoV-2 during periods of omicron and delta variant dominance: a prospective observational study from the ZOE COVID Study

Cristina Menni et al.

Summary: This study investigated the differences in symptom prevalence, risk of hospital admission, and symptom duration between omicron and delta variants of the SARS-CoV-2 virus. The study found that loss of smell was less common in omicron infections, sore throat was more common, and the rate of hospital admission was lower.

LANCET (2022)

Add to Collection

Editorial Material Medicine, General & Internal

Efficiency decreases

Halane Vaillant-Roussel et al.

EXERCER-LA REVUE FRANCOPHONE DE MEDECINE GENERALE (2022)

Add to Collection

Article Medicine, General & Internal

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

Tommy Nyberg et al.

Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.

LANCET (2022)

Add to Collection

News Item Infectious Diseases

Research in brief

Sharmila Devi

LANCET INFECTIOUS DISEASES (2022)

Add to Collection

Article Multidisciplinary Sciences

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

Roanne Keeton et al.

Summary: Despite reduced neutralizing antibody activity, T cell responses induced by vaccination or infection can cross-recognize the Omicron variant and provide protection.

NATURE (2022)

Add to Collection

Article Multidisciplinary Sciences

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Sho Iketani et al.

Summary: The identification of the Omicron variant of SARS-CoV-2 in Botswana in November 2021 sparked concern due to the spike protein alterations that could potentially evade antibodies. Further studies showed that the Omicron sublineages, BA.1+R346K and BA.2, are antigenically similar to the wild-type virus and pose similar risks to the effectiveness of current vaccines. BA.2 also demonstrated resistance to many neutralizing monoclonal antibodies, highlighting the challenges in developing effective therapeutic options.

NATURE (2022)

Add to Collection

Review Medicine, General & Internal

Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression

Daniel R. Feikin et al.

Summary: This study systematically reviewed the duration of protection provided by COVID-19 vaccines against various clinical outcomes. The findings indicate that the effectiveness or efficacy of the vaccines decreased from 1 to 6 months after full vaccination, but remained high against severe disease. Evaluating the effectiveness or efficacy of vaccines beyond 6 months is crucial for updating vaccine policies.

LANCET (2022)

Add to Collection

Article Surgery

COVID-19 in lung transplant recipients: an overview of the Swedish national experience

Jesper M. Magnusson et al.

Summary: This nationwide study focused on the impact of COVID-19 on lung transplant (LTx) recipients, revealing a spectrum of symptoms in LTx recipients with lower pre-COVID lung function associated with more severe disease presentation.

TRANSPLANT INTERNATIONAL (2021)

Add to Collection

Article Surgery

COVID-19 in solid organ transplant recipients: A national cohort study from Sweden

John M. Softeland et al.

Summary: A retrospective study on Swedish SOT recipients with COVID-19 showed that predictors of adverse outcomes include older age, male sex, higher BMI, and higher NEWS2 score. Inpatients had a higher mortality rate compared to outpatients, and antibody responses varied between patients over time.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Add to Collection

Article

COVID-19 in Solid Organ Transplantation: Results of the National COVID Cohort Collaborative

Amanda J. Vinson et al.

Transplantation Direct (2021)

Add to Collection

Editorial Material Medicine, General & Internal

SARS-CoV-2 Variants in Patients with Immunosuppression

Lawrence Corey et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Surgery

COVID-19 in solid organ transplant recipients: Initial report from the US epicenter

Marcus R. Pereira et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Add to Collection

Article Surgery

COVID-19 in solid organ transplant recipients: a single-center experience

Rogier A. S. Hoek et al.

TRANSPLANT INTERNATIONAL (2020)

Add to Collection

Article Multidisciplinary Sciences

Factors associated with COVID-19-related death using OpenSAFELY

Elizabeth J. Williamson et al.

NATURE (2020)

Add to Collection

Article Medicine, General & Internal

A global clinical measure of fitness and frailty in elderly people

K Rockwood et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.