4.7 Letter

Decrease in CD8+CD45+CCR7+CD62L+ T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

Journal

CLINICAL IMMUNOLOGY
Volume 242, Issue -, Pages -

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2022.109092

Keywords

COVID-19; T cells; Vaccination; Immune memory

Categories

Funding

  1. Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e Tecnologico do Maranhao (FAPEMA) [FAPEMA-INFRA-02012/21, COVID-19-00755/20, BATI-05406/21, BEPP-01906/21]
  2. Universidade CEUMA
  3. Universidade Federal do Maranhao

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The frequency of central memory T cells was found to decrease in individuals who were vaccinated following COVID-19 infection, emphasizing the importance of T cell responses in addition to antibody induction by vaccines.
Vaccines induce antibodies, but T cell responses are also important for protection against Coronavirus disease 2019. Here, we analyzed the frequency of memory T cells in infected and/or vaccinated individuals and observed a decrease in central memory T cells in individuals who were vaccinated following COVID-19 infection.

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