4.7 Article

Phase Ib Study of the BET Inhibitor GS-5829 as Monotherapy and Combined with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer

Related references

Note: Only part of the references are listed.
Review Oncology

Achieving clinical success with BET inhibitors as anti-cancer agents

Tatiana Shorstova et al.

Summary: Transcriptional upregulation of oncogenes drives tumor progression, and targeting BET proteins with inhibitors has shown promise in suppressing oncogenic networks in tumors. Understanding the biology of BET proteins, designing better BET inhibitors, and incorporating BET inhibitors into combination therapies can enhance their efficacy in clinical settings.

BRITISH JOURNAL OF CANCER (2021)

Review Oncology

The emerging role of BET inhibitors in breast cancer

Angeliki Andrikopoulou et al.

BREAST (2020)

Article Biochemistry & Molecular Biology

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

David Sperandio et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer

Yuqian Yan et al.

EMBO MOLECULAR MEDICINE (2019)

Review Pharmacology & Pharmacy

Bromodomain and Extraterminal Proteins as Novel Epigenetic Targets for Renal Diseases

Jose Luis Morgado-Pascual et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Urology & Nephrology

Metabolic changes in patients with prostate cancer during androgen deprivation therapy

Koji Mitsuzuka et al.

INTERNATIONAL JOURNAL OF UROLOGY (2018)

Review Oncology

BET Proteins as Targets for Anticancer Treatment

Anastasios Stathis et al.

CANCER DISCOVERY (2018)

Article Medicine, Research & Experimental

Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma

Ileabett M. Echevarria-Vargas et al.

EMBO MOLECULAR MEDICINE (2018)

Article Medicine, General & Internal

Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer

Maha Hussain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

N. D. James et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Kanak Raina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Irfan A. Asangani et al.

NATURE (2014)

Article Medicine, General & Internal

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

Emmanuel S. Antonarakis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

Howard I. Scher et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Abiraterone and Increased Survival in Metastatic Prostate Cancer

Johann S. De Bono et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Biochemistry & Molecular Biology

Molecular determinants of resistance to antiandrogen therapy

CD Chen et al.

NATURE MEDICINE (2004)