In situ monitoring of Suzuki-Miyaura cross-coupling reaction by using surface-enhanced Raman spectroscopy on a bifunctional Au-Pd nanocoronal film

Surface-enhanced Raman spectroscopy (SERS), a powerful surface vibrational spectroscopic technique, is ideally suited for in situ monitoring the chemical transformations occurred at surfaces and/or interfaces. For in situ SERS monitoring, a platform integrated both plasmonic and catalytic activity is a prerequi-site. Here, we fabricate a bifunctional Au-Pd nanocoronal film for in situ SERS monitoring Suzuki-Miyaura cross-coupling reaction. This excellent bifunctional substrate leads to the coupling of high catalytic activ-ity with a strong SERS effect at the center of two adjacent Au cores and shows fine reproducibility and stability of SERS signals. During investigating the Suzuki reaction with in situ SERS, we found two distinct catalytic kinetic processes resulted from two disparate catalytic sites on a Au-Pd nanocoronal. Comparing with conventional analytical techniques, this work provides a novel approach for studying Suzuki reac-tions at surfaces and/or interfaces with in situ SERS. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

A bifunctional Au-Pd nanocoronal film with plasmonic and catalytic activity was fabricated for in situ SERS monitoring of the Suzuki-Miyaura cross-coupling reaction. The substrate showed high catalytic activity and a strong SERS effect, leading to fine reproducibility and stability of SERS signals. This work provides a novel approach for studying Suzuki reactions at surfaces and/or interfaces with in situ SERS.