Journal
CHEMSUSCHEM
Volume 15, Issue 20, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.202201241
Keywords
amination; C-H activation; hydrogen transfer; iron; photocatalysis
Funding
- Guangdong Science and Technology Department [2019QN01L151]
- National Natural Science Foundation of China [21821003]
- Sun Yat-sen University
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An iron-catalyzed remote C(sp(3))-H amination of alcohols through 1,5-hydrogen atom transfer has been developed, providing a mild method to generate delta-C(sp(3))-N bonds from primary, secondary, and tertiary alcohols. The protocol demonstrates a wide substrate scope and good functional group tolerance.
An iron-catalyzed remote C(sp(3))-H amination of alcohols through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate delta-C(sp(3))-N bonds from primary, secondary, and tertiary alcohols under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alcohol are possible to generate the alkoxy radical intermediate.
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