Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 54, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202201644
Keywords
cross-coupling; electrophile coupling; nickel catalysis; sulfonium salts
Categories
Funding
- Spanish Government [RTI2018-095038-B-I00]
- Comunidad de Madrid [S2018/NMT-4367, Y2020/NMT-6469, SI3/PJI/2021-00520]
- CAM [PEJ-2020-AI/AMB-19182]
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In this study, a nickel-catalysed reductive cross-coupling reaction between benzyl sulfonium salts and benzyl bromides is reported. Simple, stable and readily available sulfonium salts have shown their ability as leaving groups in cross-electrophile coupling, allowing the formation of challenging sp(3)-sp(3) carbon-carbon bonds for the synthesis of interesting dihydrostilbene derivatives. Additionally, benzyl tosyl derivatives have been demonstrated to be suitable substrates for reductive cross-coupling by in-situ formation of the corresponding sulfonium salt.
A nickel-catalysed reductive cross-coupling reaction between benzyl sulfonium salts and benzyl bromides is reported. Simple, stable and readily available sulfonium salts have shown their ability as leaving groups in cross-electrophile coupling, allowing the formation of challenging sp(3)-sp(3) carbon-carbon bonds, towards the synthesis of interesting dihydrostilbene derivatives. In addition, benzyl tosyl derivatives have been demonstrated to be suitable substrates for reductive cross-coupling by in-situ formation of the corresponding sulfonium salt.
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