Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 28, Issue 63, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202202299
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Funding
- French National Research Agency [ANR 18-CE07-0039-01]
- CNRS
- French Ministry of Research
- French Fluorine Network (GIS-FLUOR)
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This article describes a palladium-catalyzed trifluoromethylselenolation reaction of vinylic C-H bonds. The reaction utilizes 5-methoxy-8-aminoquinoline as an auxiliary directing group, and gives excellent yields regardless of the nature of the substituents.
Trifluorometylselenolation via C-H activation is barely described in literature. In particular, no such vinylic functionalization has been yet described. Herein, a palladiumcatalyzed trifluoromethylselenolation of vinylic C-H bonds is described. The 5-methoxy-8-aminoquinoline has been used as auxiliary directing group to perform this reaction. The reaction gives excellent yields with a-substituted compounds whatever the substituents and a microwave activation can be used to accelerate the reaction. With beta-substituted substrates lower yields, but still satisfactory, are obtained. This methodology was also successfully extended to other fluoroalkylselenyl groups.
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