4.2 Article

Synthesis of Ibuprofen Conjugates with Betulin, Allobetulin, and Betulinic Acid

Journal

CHEMISTRY OF NATURAL COMPOUNDS
Volume 58, Issue 4, Pages 679-683

Publisher

SPRINGER
DOI: 10.1007/s10600-022-03768-w

Keywords

betulin; allobetulin; betulinic acid; ibuprofen; conjugates; Steglich reaction; acid-chloride method

Funding

  1. RAS Program Basic Principles of Chemistry, Topic No. 8, Chemo-, Regio-, and Stereoselective Transformations of Terpenoids, Steroids, and Lipids in Targeted Synthesis of Low-molecular-mass Bioregulators [AAAA-A17-117011910023-2]

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Syntheses of mono- and diester derivatives of betulin, allobetulin, and betulinic acid with ibuprofen using Steglich condensation or acid-chloride coupling are reported.
Syntheses of mono- and diester derivatives of betulin, allobetulin, and betulinic acid with ibuprofen that were based on Steglich condensation or acid-chloride coupling are reported.

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