Naphthalimide derivatives as fluorescent probes for imaging endogenous gasotransmitters

Gasotransmitters have gained significant recognition attributed to their evident biological impacts, and is accepted as a promising and less-explored area with immense research scope. The three-member family comprising of nitric oxide, carbon monoxide and hydrogen sulphide as endogenous gaseous signaling molecules have been found to elicit a plethora of crucial biological functions, spawning a new research area. The sensing of these small molecules is vital to gain deeper insights into their functions, as they can act both as a friend or a foe in mammalian systems. The initial sections of the review present the physiological and pathophysiological roles of these endogenous gas transmitters and their synergistic interactions. Further, various detection approaches, especially the usage of fascinating features of 1,8-naphthalimide as fluorescent probe in the detection and monitoring of these small signaling molecules are highlighted. The current limitations and the future scope of improving the sensing of the three gasotransmitters are also discussed.

Automated summary

Gasotransmitters are a promising and less-explored area of research, as they have significant biological impacts and can act as both friend and foe in mammalian systems. This review highlights the physiological and pathophysiological roles of these endogenous gas transmitters, as well as their synergistic interactions. It also discusses various detection approaches, with a focus on the usage of 1,8-naphthalimide as a fluorescent probe for the detection and monitoring of these small signaling molecules.