Journal
CHEMICAL REVIEWS
Volume 122, Issue 13, Pages 11701-11758Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.2c00029
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Funding
- National Science Foundation [CHE-1800350]
- National Institute of General Medical Sciences [GM111835]
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Advances in synthetic carbohydrate chemistry have improved access to common glycans, but challenges remain. Glycosyl halides play a crucial role in glycosylation.
Advances in synthetic carbohydrate chemistry have dramatically improved access to common glycans. However, many novel methods still fail to adequately address challenges associated with chemical glycosylation and glycan synthesis. Since a challenge of glycosylation has remained, scientists have been frequently returning to the traditional glycosyl donors. This review is dedicated to glycosyl halides that have played crucial roles in shaping the field of glycosciences and continue to pave the way toward our understanding of chemical glycosylation.
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