Journal
CEPHALALGIA
Volume 42, Issue 13, Pages 1323-1330Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/03331024221111526
Keywords
Erenumab; fremanezumab; galcanezumab; CGRP; migraine symptoms; chronic migraine
Categories
Ask authors/readers for more resources
Anti-calcitonin gene-related peptide antibodies appear to have a significant impact on the prodromal and accompanying symptoms of migraine, reducing the frequency and intensity of migraine attacks.
Background Clinical trials and observational studies with anti-calcitonin gene-related peptide antibodies poorly investigated their impact on migraine prodromal and accompanying symptoms. This information might help deciphering the biologics' pharmacodynamic and provide hints on migraine pathogenesis. Herein, we report the effects of erenumab, fremanezumab and galcanezumab on attack prodromal and accompanying symptoms and on neurological and psychiatric traits. Methods An explorative, prospective, questionnaire-based study was completed by a cohort (n = 80) of patients with chronic migraine patients presenting a sustained reduction of >= 50% of Migraine Disability Assessment Score and >= 30% of monthly migraine days three months after anti-calcitonin gene-related peptide antibodies treatment. Results The majority of patients experienced a complete prevention of migraine symptoms without evidence of initial onset followed by attack abortion. Few patients reported the recurrence of prodromal (from 10% to 12.5%) or accompanying (from 1.3% to 8.8%) symptoms without headache. All patients with migraine with aura reported a decrease of aura incidence. Sleep changes (51.2%), increase in appetite (20.0%) and weight (18.8%) as well as a reduction in stress (45.0%), anxiety (26.3%), and panic attacks (15%) were also reported. Conclusion Anti-calcitonin gene-related peptide antibodies seems to significantly impact brain functions of migraineurs, preventing not only migraine headache but also its anticipatory and accompanying symptoms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available